APOBEC3D

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
Identifiers
Symbols	APOBEC3D ; A3D; APOBEC3DE; APOBEC3E; ARP6
External IDs	OMIM: 609900 HomoloGene: 122788 GeneCards: APOBEC3D Gene
EC number	3.5.4.-
Gene ontology Molecular function • zinc ion binding • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Cellular component • cytoplasmic mRNA processing body • cytoplasm Biological process • negative regulation of transposition • innate immune response • negative regulation of single stranded viral RNA replication via double stranded DNA intermediate • defense response to virus • DNA cytosine deamination Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	140564	n/a
Ensembl	ENSG00000243811	n/a
UniProt	Q96AK3	n/a
RefSeq (mRNA)	NM_152426	n/a
RefSeq (protein)	NP_689639	n/a
Location (UCSC)	Chr 22: 39.01 – 39.03 Mb	n/a
PubMed search		n/a

Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene.^[1][2]

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.^[2]

References

1. Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.
2. "Entrez Gene: APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative)".

Further reading

• Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business". Trends Genet. 19 (4): 207–16. doi:10.1016/S0168-9525(03)00054-4. PMID 12683974.
• Harris RS, Liddament MT (2004). "Retroviral restriction by APOBEC proteins". Nat. Rev. Immunol. 4 (11): 868–77. doi:10.1038/nri1489. PMID 15516966.
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mariani R, Chen D, Schröfelbauer B; et al. (2003). "Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif". Cell 114 (1): 21–31. doi:10.1016/S0092-8674(03)00515-4. PMID 12859895.
• Sawyer SL, Emerman M, Malik HS (2006). "Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G". PLoS Biol. 2 (9): E275. doi:10.1371/journal.pbio.0020275. PMC 479043. PMID 15269786.
• Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Dang Y, Wang X, Esselman WJ, Zheng YH (2006). "Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family". J. Virol. 80 (21): 10522–33. doi:10.1128/JVI.01123-06. PMC 1641744. PMID 16920826.
• Kinomoto M, Kanno T, Shimura M; et al. (2007). "All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition". Nucleic Acids Res. 35 (9): 2955–64. doi:10.1093/nar/gkm181. PMC 1888823. PMID 17439959.