APOBEC4
| Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | APOBEC4 ; C1orf169 | ||||||||||
| External IDs | OMIM: 609908 MGI: 1918531 HomoloGene: 52415 GeneCards: APOBEC4 Gene | ||||||||||
| EC number | 3.5.4.- | ||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 403314 | 71281 | |||||||||
| Ensembl | ENSG00000173627 | ENSMUSG00000055547 | |||||||||
| UniProt | Q8WW27 | Q497M3 | |||||||||
| RefSeq (mRNA) | NM_203454 | NM_001081197 | |||||||||
| RefSeq (protein) | NP_982279 | NP_001074666 | |||||||||
| Location (UCSC) |
Chr 1: 183.65 – 183.65 Mb |
Chr 1: 152.75 – 152.76 Mb | |||||||||
| PubMed search | |||||||||||
C->U-editing enzyme APOBEC-4, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4, is a protein that in humans is encoded by the APOBEC4 gene.[1][2]
Function
This gene encodes a member of the AID / APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection.[2]
References
- ↑ Rogozin IB, Basu MK, Jordan IK, Pavlov YI, Koonin EV (September 2005). "APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis". Cell Cycle 4 (9): 1281–5. doi:10.4161/cc.4.9.1994. PMID 16082223.
- 1 2 "Entrez Gene: apolipoprotein B mRNA editing enzyme".
Further reading
- Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Prochnow C, Bransteitter R, Chen XS (2009). "APOBEC deaminases-mutases with defensive roles for immunity.". Sci. China, C, Life Sci. 52 (10): 893–902. doi:10.1007/s11427-009-0133-1. PMID 19911124.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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