(3-Aminopropyl)triethoxysilane

(3-Aminopropyl)triethoxysilane

Structural formula of (3-aminopropyl)triethoxysilane
Identifiers
CAS Number	919-30-2
ChemSpider	12933
Jmol interactive 3D	Image
PubChem	13521
InChI InChI=1S/C9H23NO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-10H2,1-3H3 Key: WYTZZXDRDKSJID-UHFFFAOYSA-N InChI=1/C9H23NO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-10H2,1-3H3 Key: WYTZZXDRDKSJID-UHFFFAOYAI
SMILES CCO[Si](CCCN)(OCC)OCC
Properties
Chemical formula	C9H23NO3Si
Molar mass	221.37 g·mol^−1
Density	0.946 g/mL[1]
Melting point	−70 °C (−94 °F; 203 K)
Boiling point	217 °C (423 °F; 490 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

(3-Aminopropyl)triethoxysilane (APTES) is an aminosilane frequently used in the process of silanization, the functionalization of surfaces with alkoxysilane molecules.

Use with PDMS

APTES can be used to covalently bond thermoplastics to poly(dimethylsiloxane) (PDMS).^[2] Thermoplastics are treated with oxygen plasma to functionalize surface molecules, and subsequently coated with an aqueous 1% by volume APTES solution. PDMS is treated with oxygen plasma and placed in contact with the functionalized thermoplastic surface. A stable, covalent bond forms within 2 minutes.

Use with cell cultures

APTES-functionalized surfaces have been shown to be nontoxic to embryonic rat cardiomyocytes in vitro.^[3] Further experimentation is needed to evaluate toxicity to other cell types in extended culture.

Toxicity

APTES is a toxic compound with an MSDS health hazard score of 3.^[4] APTES fumes are destructive to the mucous membranes and the upper respiratory tract, and should be used in a fume hood with gloves. If a fume hood is not available, a face shield and full face respirator must be implemented. The target organs of APTES are nerves, liver and kidney.

References

1. "3-Aminopropyltriethoxysilane | 919-30-2". Chemicalbook.com. Retrieved 2012-08-01.
2. Sunkara V., Park D.K., Hwang H., Chantiwas R., Soper S.A., and Cho Y.K. (2011). Simple room temperature bonding of thermoplastics and poly(dimethylsiloxane). Lab on a Chip, 11(5), 962-965
3. Natarajan, Growth and Electrophysiological Properties of Rat Embryonic Cardiomyocytes on Hydroxyl- and Carboxyl-Modified Surfaces, J Biomater Sci Polym Ed 2010
4. 281778 - (3-Aminopropyl)trimethoxysilane. "(3-Aminopropyl)trimethoxysilane 97%". Sigma-Aldrich. Retrieved 2012-08-01.