ASCC3

Activating signal cointegrator 1 complex subunit 3
Identifiers
Symbols	ASCC3 ; ASC1p200; HELIC1; RNAH
External IDs	OMIM: 614217 MGI: 1925237 HomoloGene: 4973 GeneCards: ASCC3 Gene
EC number	3.6.4.12
Gene ontology Molecular function • protein binding • ATP binding • ATP-dependent 3'-5' DNA helicase activity • poly(A) RNA binding Cellular component • intracellular • nucleus • nucleoplasm • cytoplasm • Golgi apparatus • membrane Biological process • DNA repair • DNA dealkylation involved in DNA repair • transcription, DNA-templated • regulation of transcription, DNA-templated • cell proliferation • DNA duplex unwinding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10973	77987
Ensembl	ENSG00000112249	ENSMUSG00000038774
UniProt	Q8N3C0	E9PZJ8
RefSeq (mRNA)	NM_001284271	NM_198007
RefSeq (protein)	NP_001271200	NP_932124
Location (UCSC)	Chr 6: 100.51 – 100.88 Mb	Chr 10: 50.59 – 50.85 Mb
PubMed search

Activating signal cointegrator 1 complex subunit 3 is a protein that in humans is encoded by the ASCC3 gene.^[1][2]

Interactions

ASCC3 has been shown to interact with RELA,^[3] C-jun^[3] and Serum response factor.^[3]

References

1. Coulie PG, Ikeda H, Baurain JF, Chiari R (Jun 1999). "Antitumor immunity at work in a melanoma patient". Advances in Cancer Research. Advances in Cancer Research 76: 213–42. doi:10.1016/S0065-230X(08)60778-2. ISBN 978-0-12-006676-6. PMID 10218103.
2. "Entrez Gene: ASCC3 activating signal cointegrator 1 complex subunit 3".
3. Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (Jul 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Molecular and Cellular Biology 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.

Further reading

• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (Jul 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Molecular and Cellular Biology 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.