Acetylcorynoline

Acetylcorynoline
Identifiers

CAS Number	18797-80-3
ChemSpider	154160
Jmol interactive 3D	Image
PubChem	177015
InChI InChI=1S/C23H23NO6/c1-12(25)30-20-7-13-6-18-19(28-10-27-18)8-14(13)22-23(20,2)16-4-5-17-21(29-11-26-17)15(16)9-24(22)3/h4-6,8,20,22H,7,9-11H2,1-3H3/t20-,22+,23-/m0/s1 Key: PUHCFWFODBLSAP-WWNPGLIZSA-N InChI=1/C23H23NO6/c1-12(25)30-20-7-13-6-18-19(28-10-27-18)8-14(13)22-23(20,2)16-4-5-17-21(29-11-26-17)15(16)9-24(22)3/h4-6,8,20,22H,7,9-11H2,1-3H3/t20-,22+,23-/m0/s1 Key: PUHCFWFODBLSAP-WWNPGLIZBS
SMILES CC(=O)O[C@H]1CC2=CC3=C(C=C2[C@@H]4[C@]1(C5=C(CN4C)C6=C(C=C5)OCO6)C)OCO3
Properties
Chemical formula	C₂₃H₂₃NO₆
Molar mass	409.44 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Acetylcorynoline is a bio-active isolate of Corydalis ambigua. It inhibits the maturing of bone marrow-derived dendritic cells in mice. However, it is only cytotoxic in amounts of greater than 20 μM.^[1]

References

↑ Fu, RH; Wang, YC; Liu, SP; Chu, CL; Tsai, RT; Ho, YC; Chang, WL; Chiu, SC; Harn, HJ; Shyu, WC; Lin, SZ (2013). Caldwell, Charles C, ed. "Acetylcorynoline impairs the maturation of mouse bone marrow-derived dendritic cells via suppression of IκB kinase and mitogen-activated protein kinase activities". PLOS ONE 8 (3): e58398. doi:10.1371/journal.pone.0058398. PMC 3589392. PMID 23472193.

External links

Protective action of corynoline, acetylcorynoline and protopine against experimental liver injury in mice

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