All-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific)

All-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific)
Identifiers
EC number	2.5.1.84
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

All-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) (EC 2.5.1.84, nonaprenyl diphosphate synthase, solanesyl diphosphate synthase, SolPP synthase, SPP-synthase, SPP synthase, solanesyl-diphosphate synthase, OsSPS2) is an enzyme with systematic name geranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 7 isopentenyl units).^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

geranyl diphosphate + 7 isopentenyl diphosphate $\rightleftharpoons$ 7 diphosphate + all-trans-nonaprenyl diphosphate

This enzyme is involved in the synthesis of the side chain of menaquinone-9.

References

1. Sagami, H., Ogura, K. and Seto, S. (1977). "Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus". Biochemistry 16: 4616–4622. doi:10.1021/bi00640a014. PMID 911777.
2. Fujii, H., Sagami, H., Koyama, T., Ogura, K., Seto, S., Baba, T. and Allen, C.M. (1980). "Variable product specificity of solanesyl pyrophosphate synthetase". Biochem. Biophys. Res. Commun. 96: 1648–1653. doi:10.1016/0006-291X(80)91363-7. PMID 7447947.
3. Ohara, K., Sasaki, K. and Yazaki, K. (2010). "Two solanesyl diphosphate synthases with different subcellular localizations and their respective physiological roles in Oryza sativa". J. Exp. Bot. 61 (10): –. doi:10.1093/jxb/erq103. PMID 20421194.
4. Ohnuma, S., Koyama, T. and Ogura, K. (1991). "Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase". J. Biol. Chem. 266 (35): 23706–23713. PMID 1748647.
5. Gotoh, T., Koyama, T. and Ogura, K. (1992). "Farnesyl diphosphate synthase and solanesyl diphosphate synthase reactions of diphosphate-modified allylic analogs: the significance of the diphosphate linkage involved in the allylic substrates for prenyltransferase". J. Biochem. 112 (1): 20–27. PMID 1429508.
6. Teclebrhan, H., Olsson, J., Swiezewska, E. and Dallner, G. (1993). "Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes". J. Biol. Chem. 268 (31): 23081–23086. PMID 8226825.

External links

• All-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) at the US National Library of Medicine Medical Subject Headings (MeSH)