All-trans-nonaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific)

All-trans-nonaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) (EC 2.5.1.85, nonaprenyl diphosphate synthase, solanesyl diphosphate synthase, At-SPS2, At-SPS1, SPS1, SPS2) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 5 isopentenyl units).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + 5 isopentenyl diphosphate

\rightleftharpoons

5 diphosphate + all-trans-nonaprenyl diphosphate

Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate.

References

↑ Hirooka, K., Bamba, T., Fukusaki, E. and Kobayashi, A. (2003). "Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase". Biochem. J. 370 (Pt 2): 679–686. doi:10.1042/BJ20021311. PMC 1223189. PMID 12437513.
↑ Hirooka, K., Izumi, Y., An, C.I., Nakazawa, Y., Fukusaki, E. and Kobayashi, A. (2005). "Functional analysis of two solanesyl diphosphate synthases from Arabidopsis thaliana". Biosci. Biotechnol. Biochem. 69 (3): 592–601. doi:10.1271/bbb.69.592. PMID 15784989.
↑ Jun, L., Saiki, R., Tatsumi, K., Nakagawa, T. and Kawamukai, M. (2004). "Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana". Plant Cell Physiol. 45 (12): 1882–1888. doi:10.1093/pcp/pch211. PMID 15653808.

External links

All-trans-nonaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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