Antony Galione

Antony Galione
Born Antony Giuseppe Galione
(1963-09-13) September 13, 1963[1]
Chelmsford[1]
Fields
Institutions
Alma mater University of Cambridge (BA, PhD)
Thesis Oscillations in intracellular calcium in the blowfly salivary gland (1989)
Doctoral advisor Michael Berridge[3]
Doctoral students
  • Kai-Ting Chuang[4]
  • Timothy Funnell[5]
  • Paula Heister[6]
  • Sarah Howles[7]
Notable awards
Website
www.pharm.ox.ac.uk/research/antony-galione

Antony Giuseppe Galione (born 1963)[1] FRS[8] FMedSci is Professor of Pharmacology and Wellcome Trust Senior Investigator in the Department of Pharmacology at the University of Oxford.[3]

Education

Galione was educated at Felsted School[1] in Essex and Trinity College, Cambridge where he was awarded a Bachelor of Arts degree in Natural Sciences (Pharmacology) in 1985.[3] He was awarded his PhD in 1989 for research on calcium signalling in the blowfly salivary gland supervised by Michael Berridge.[9][10]

Research

Galione's research investigates calcium signalling.[2] He established the concept of multiple calcium mobilizing messengers which link cell surface stimuli to release of internal calcium stores, and identified their target two-pore channels (TPCs) and organelles.[11] This has enhanced our understanding of how calcium as a ubiquitous cellular regulator may control a myriad of cellular processes with precision.[8]

He established that cyclic ADP-ribose regulates calcium-induced calcium release and globalization of calcium signals,[12] and that Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous trigger for initiating and coordinating calcium signals, often involving communication between organelles at contact sites.[8]

By developing novel pharmacological, molecular and physiological approaches, he has demonstrated that these messengers and their targets regulate many fundamental pathophysiological cellular processes as diverse as Ebola virus disease infection, fertilisation and embryology, cardiac contractility, T cell activation and neuronal excitability. The discovery of lysosomes as calcium stores mobilized by NAADP has identified an entirely new signalling role for these organelles in health and disease.[8][13]

Awards and honours

Galione was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2010[8] and was head of the Department of Pharmacology at the University of Oxford from 2006 until 2015. He was elected a Fellow of the Royal Society (FRS) in 2016.[8]

References

  1. 1 2 3 4 GALIONE, Prof. Antony Giuseppe. Who's Who 2016 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
  2. 1 2 Antony Galione's publications indexed by Google Scholar, a service provided by Google
  3. 1 2 3 "Professor Antony Galione FMedSci FRS". Oxford: ox.ac.uk. Archived from the original on 2016-03-23.
  4. ↑ Chuang, Kai-Ting (2011). Characterization of mouse two-pore channels (TPCs) in NAADP-mediated Ca(2+) signalling (DPhil thesis). University of Oxford.
  5. ↑ Funnell, Timothy (2011). Characterisation of the human two-pore channels (DPhil thesis). University of Oxford.
  6. ↑ Heister, Paula Maria (2012). The role of two pore channels (TPCs) in pancreatic beta cell stimulus-secretion coupling (DPhil thesis). University of Oxford.
  7. ↑ Howles, Sarah Anne (2015). The role of the G-protein subunit, G-α-11, and the adaptor protein 2 sigma subunit, ap2-σ-2, in the regulation of calcium homeostasis (DPhil thesis). University of Oxford.
  8. 1 2 3 4 5 6 7 "Professor Antony Galione FMedSci FRS". London: Royal Society. Archived from the original on 2016-04-29. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived September 25, 2015)
  9. ↑ Galione, Antony Giuseppe (1989). Oscillations in intracellular calcium in the blowfly salivary gland. (PhD thesis). University of Cambridge. OCLC 53486297.
  10. ↑ Berridge MJ, Galione A (1988). "Cytosolic calcium oscillators.". The FASEB Journal 2 (15): 3074–82. PMID 2847949.
  11. ↑ Calcraft, Peter J.; Ruas, Margarida; Pan, Zui; Cheng, Xiaotong; Arredouani, Abdelilah; Hao, Xuemei; Tang, Jisen; Rietdorf, Katja; Teboul, Lydia; Chuang, Kai-Ting; Lin, Peihui; Xiao, Rui; Wang, Chunbo; Zhu, Yingmin; Lin, Yakang; Wyatt, Christopher N.; Parrington, John; Ma, Jianjie; Evans, A. Mark; Galione, Antony; Zhu, Michael X. (2009). "NAADP mobilizes calcium from acidic organelles through two-pore channels". Nature 459 (7246): 596–600. doi:10.1038/nature08030.
  12. ↑ Galione, A.; Lee, H.; Busa, W. (1991). "Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose". Science 253 (5024): 1143–1146. doi:10.1126/science.1909457.
  13. ↑ Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T; et al. (2015). "Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.". Journal of Biological Chemistry 290 (35): 21376–92. doi:10.1074/jbc.M115.671248. PMC 4571866. PMID 26152717.


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