Apolipoprotein C4

Apolipoprotein C-IV
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1BY6​, 1I5J​, 1O8T​, 1SOH​
Identifiers
Symbols	APOC4 ; APO-CIV; APOC-IV
External IDs	OMIM: 600745 MGI: 87878 HomoloGene: 1245 GeneCards: APOC4 Gene
Gene ontology Molecular function • lipid transporter activity Cellular component • very-low-density lipoprotein particle • high-density lipoprotein particle Biological process • lipid metabolic process • lipid transport • positive regulation of sequestering of triglyceride • triglyceride homeostasis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	346	11425
Ensembl	ENSG00000267467	ENSMUSG00000074336
UniProt	P55056	Q61268
RefSeq (mRNA)	NM_001646	NM_007385
RefSeq (protein)	NP_001637	NP_031411
Location (UCSC)	Chr 19: 44.94 – 44.95 Mb	Chr 7: 19.68 – 19.68 Mb
PubMed search

Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene.^[1][2]

Function

Apolipoprotein (apo)C4 gene is a member of the apolipoprotein C gene family. It is expressed in the liver and has a predicted protein structure characteristic of the other genes in this family. Apo C4 is a 3.3-kb gene consisting of 3 exons and 2 introns; it is located 0.5 kb 5' to the APOC2 gene.^[1]

References

1. "Entrez Gene: apolipoprotein C-IV".
2. Allan CM, Walker D, Segrest JP, Taylor JM (July 1995). "Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus". Genomics 28 (2): 291–300. doi:10.1006/geno.1995.1144. PMID 8530039.

Further reading

• Kim E, Li K, Lieu C; et al. (2008). "Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis.". J. Hepatol. 49 (5): 787–98. doi:10.1016/j.jhep.2008.06.029. PMC 2644636. PMID 18809223.
• Burkhardt R, Kenny EE, Lowe JK; et al. (2008). "Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13". Arterioscler. Thromb. Vasc. Biol. 28 (11): 2078–84. doi:10.1161/ATVBAHA.108.172288. PMC 2764366. PMID 18802019.
• Willer CJ, Sanna S, Jackson AU; et al. (2008). "Newly identified loci that influence lipid concentrations and risk of coronary artery disease". Nat. Genet. 40 (2): 161–9. doi:10.1038/ng.76. PMID 18193043.
• Mak PA, Laffitte BA, Desrumaux C; et al. (2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta". J. Biol. Chem. 277 (35): 31900–8. doi:10.1074/jbc.M202993200. PMID 12032151.
• Liu T, Qian WJ, Gritsenko MA; et al. (2005). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Kathiresan S, Willer CJ, Peloso GM; et al. (2009). "Common variants at 30 loci contribute to polygenic dyslipidemia". Nat. Genet. 41 (1): 56–65. doi:10.1038/ng.291. PMC 2881676. PMID 19060906.
• Mosbruger TL, Duggal P, Goedert JJ; et al. (2010). "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus". J. Infect. Dis. 201 (9): 1371–80. doi:10.1086/651606. PMC 2853721. PMID 20331378.
• Ken-Dror G, Talmud PJ, Humphries SE, Drenos F (2010). "APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective Coronary Heart Disease Risk among UK healthy men". Molecular medicine (Cambridge, Mass.) 16 (9–10): 389–99. doi:10.2119/molmed.2010.00044. PMC 2935949. PMID 20498921.
• Marques-Vidal P, Bochud M, Paccaud F; et al. (2010). "No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels". Atherosclerosis 211 (2): 551–7. doi:10.1016/j.atherosclerosis.2010.04.001. PMID 20430392.
• Talmud PJ, Drenos F, Shah S; et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Drenos F, Talmud PJ, Casas JP; et al. (2009). "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Hum. Mol. Genet. 18 (12): 2305–16. doi:10.1093/hmg/ddp159. PMC 2685759. PMID 19336475.
• Kathiresan S, Melander O, Guiducci C; et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans". Nat. Genet. 40 (2): 189–97. doi:10.1038/ng.75. PMC 2682493. PMID 18193044.
• Mancone C, Amicone L, Fimia GM; et al. (2007). "Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF". Proteomics 7 (1): 143–54. doi:10.1002/pmic.200600339. PMID 17154273.
• Lowe JK, Maller JB, Pe'er I; et al. (2009). Gibson, Greg, ed. "Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae". PLoS Genet. 5 (2): e1000365. doi:10.1371/journal.pgen.1000365. PMC 2628735. PMID 19197348.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kamboh MI, Aston CE, Hamman RF (2000). "DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile". Atherosclerosis 152 (1): 193–201. doi:10.1016/S0021-9150(99)00459-1. PMID 10996355.
• Klos KL, Sing CF, Boerwinkle E; et al. (2006). "Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants". Arterioscler. Thromb. Vasc. Biol. 26 (8): 1828–36. doi:10.1161/01.ATV.0000231523.19199.45. PMID 16763159.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kotite L, Zhang LH, Yu Z; et al. (2003). "Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins". J. Lipid Res. 44 (7): 1387–94. doi:10.1194/jlr.M300087-JLR200. PMID 12700345.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.