Arachidonoyl trifluoromethyl ketone

Arachidonyl trifluoromethyl ketone (ATK) is an analog of arachidonic acid.[1] that inhibits some isoforms of the enzyme phospholipase A2.[2] Specifically it inhibits the 85 kDa cystolic PLA2 (cPLA2).[2]

It has been studied as a neuroprotective agent after spinal cord injury,[2][3] and in animal models of multiple sclerosis.[4]

See also

References

  1. ↑ Street, I.P., Lin, H., Laliberté, F., et al. Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2. Biochemistry 32 5935-5940 (1993).
  2. 1 2 3 Khan; et al. (2015). "Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats.". doi:10.1186/s12974-015-0311-y.
  3. ↑ Huang et al. (2009). "Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury.". J Neurotrauma. 2009 Aug;26(8):1429-34. doi:10.1089/neu.2008-0835.
  4. ↑ Vana et al. "Arachidonyl trifluoromethyl ketone ameliorates experimental autoimmune encephalomyelitis via blocking peroxynitrite formation in mouse spinal cord white matter.". Experimental Neurology Vol 231, Issue 1, Sept 2011, Pages 45–55. doi:10.1016/j.expneurol.2011.05.014.

External links


This article is issued from Wikipedia - version of the Tuesday, February 16, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.