Unspecific peroxygenase

Unspecific peroxygenase
Identifiers
EC number 1.11.2.1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Unspecific peroxygenase (EC 1.11.2.1, aromatic peroxygenase, mushroom peroxygenase, haloperoxidase-peroxygenase, Agrocybe aegerita peroxidase) is an enzyme with systematic name substrate:hydrogen peroxide oxidoreductase (RH-hydroxylating or -epoxidising).[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction

RH + H2O2 \rightleftharpoons ROH + H2O

Unspecific peroxygenase is a heme-thiolate protein comparable to Cytochrome_P450 in the ability to catalyze a variety of P450 reactions (hence "unspecific"), but forms a unique, solely fungal, protein family of extracellular enzymes.

References

  1. ↑ Ullrich, R., Nuske, J., Scheibner, K., Spantzel, J. and Hofrichter, M. (2004). "Novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes". Appl. Environ. Microbiol. 70 (8): 4575–4581. doi:10.1128/AEM.70.8.4575-4581.2004. PMC 492325. PMID 15294788.
  2. ↑ Ullrich, R. and Hofrichter, M. (2005). "The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene". FEBS Lett. 579 (27): 6247–6250. doi:10.1016/j.febslet.2005.10.014. PMID 16253244.
  3. ↑ Anh, D.H., Ullrich, R., Benndorf, D., Svatos, A., Muck, A. and Hofrichter, M. (2007). "The coprophilous mushroom Coprinus radians secretes a haloperoxidase that catalyzes aromatic peroxygenation". Appl. Environ. Microbiol. 73 (17): 5477–5485. doi:10.1128/AEM.00026-07. PMC 2042081. PMID 17601809.
  4. ↑ Ullrich, R., Dolge, C., Kluge, M. and Hofrichter, M. (2008). "Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita". FEBS Lett. 582 (29): 4100–4106. doi:10.1016/j.febslet.2008.11.006. PMID 19022254.
  5. ↑ Aranda, E., Kinne, M., Kluge, M., Ullrich, R. and Hofrichter, M. (2009). "Conversion of dibenzothiophene by the mushrooms Agrocybe aegerita and Coprinellus radians and their extracellular peroxygenases". Appl. Microbiol. Biotechnol. 82 (6): 1057–1066. doi:10.1007/s00253-008-1778-6. PMID 19039585.
  6. ↑ Kinne, M., Poraj-Kobielska, M., Aranda, E., Ullrich, R., Hammel, K.E., Scheibner, K. and Hofrichter, M. (2009). "Regioselective preparation of 5-hydroxypropranolol and 4′-hydroxydiclofenac with a fungal peroxygenase". Bioorg. Med. Chem. Lett. 19 (11): 3085–3087. doi:10.1016/j.bmcl.2009.04.015. PMID 19394224.
  7. ↑ Kluge, M., Ullrich, R., Dolge, C., Scheibner, K. and Hofrichter, M. (2009). "Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H2O2 and intermediary epoxidation". Appl. Microbiol. Biotechnol. 81 (6): 1071–1076. doi:10.1007/s00253-008-1704-y. PMID 18815784.
  8. ↑ Kinne, M., Poraj-Kobielska, M., Ralph, S.A., Ullrich, R., Hofrichter, M. and Hammel, K.E. (2009). "Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase". J. Biol. Chem. 284: 29343–29349. doi:10.1074/jbc.M109.040857. PMC 2785565. PMID 19713216.
  9. ↑ Pecyna, M.J., Ullrich, R., Bittner, B., Clemens, A., Scheibner, K., Schubert, R. and Hofrichter, M. (2009). "Molecular characterization of aromatic peroxygenase from Agrocybe aegerita". Appl. Microbiol. Biotechnol. 84 (5): 885–897. doi:10.1007/s00253-009-2000-1. PMID 19434406.

External links

This article is issued from Wikipedia - version of the Wednesday, March 30, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.