Arylacetonitrilase

arylacetonitrilase
Identifiers
EC number	3.5.5.5
CAS number	132053-06-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an arylacetonitrilase (EC 3.5.5.5) is an enzyme that catalyzes the chemical reaction

4-chlorophenylacetonitrile + 2 H₂O $\rightleftharpoons$ 4-chlorophenylacetate + NH₃

Thus, the two substrates of this enzyme are 4-chlorophenylacetonitrile and H₂O, whereas its two products are 4-chlorophenylacetate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is arylacetonitrile aminohydrolase. This enzyme participates in cyanoamino acid metabolism.

References

• Mauger J, Nagasawa T and Yamada H (1990). "Occurrence of a novel nitrilase, arylacetonitrilase, in Alcaligenes faecalis JM3". Arch. Microbiol. 155: 1–6. doi:10.1007/BF00291265.
• Nagasawa T, Mauger J, Yamada H (1990). "A novel nitrilase, arylacetonitrilase, of Alcaligenes faecalis JM3 Purification and characterization". Eur. J. Biochem. 194 (3): 765–72. doi:10.1111/j.1432-1033.1990.tb19467.x. PMID 2269298.