Autophagy-related protein 13

Autophagy related 13
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3WAN, 3WAO, 3WAP
Identifiers
Symbols	ATG13 ; KIAA0652; PARATARG8
External IDs	OMIM: 615088 MGI: 1196429 HomoloGene: 32229 GeneCards: ATG13 Gene
Gene ontology Molecular function • protein binding • protein kinase binding Cellular component • pre-autophagosomal structure • mitochondrion • cytosol • ATG1/UKL1 kinase complex Biological process • autophagosome assembly • activation of mitophagy in response to mitochondrial depolarization • positive regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9776	51897
Ensembl	ENSG00000175224	ENSMUSG00000027244
UniProt	O75143	Q91YI1
RefSeq (mRNA)	NM_001142673	NM_145528
RefSeq (protein)	NP_001136145	NP_663503
Location (UCSC)	Chr 11: 46.62 – 46.67 Mb	Chr 2: 91.67 – 91.71 Mb
PubMed search

Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene.^[1]

ATG13 is an autophagy factor required for phagosome formation. ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.^[2][3][4]

References

1. "Entrez Gene: KIAA0652".
2. Mercer CA, Kaliappan A, Dennis PB (July 2009). "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy". Autophagy 5 (5): 649–62. doi:10.4161/auto.5.5.8249. PMID 19287211.
3. Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N (April 2009). "Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy". Mol. Biol. Cell 20 (7): 1981–91. doi:10.1091/mbc.E08-12-1248. PMC 2663915. PMID 19211835.
4. Chan EY, Longatti A, McKnight NC, Tooze SA (January 2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC 2612494. PMID 18936157.

Further reading

• Hosokawa N, Sasaki T, Iemura S; et al. (2009). "Atg101, a novel mammalian autophagy protein interacting with Atg13". Autophagy 5 (7): 973–9. doi:10.4161/auto.5.7.9296. PMID 19597335.
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Chan EY (2009). "mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex". Science Signaling 2 (84): pe51. doi:10.1126/scisignal.284pe51. PMID 19690328.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Jung CH, Jun CB, Ro SH; et al. (2009). "ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery". Mol. Biol. Cell 20 (7): 1992–2003. doi:10.1091/mbc.E08-12-1249. PMC 2663920. PMID 19225151.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ishikawa K, Nagase T, Suyama M; et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Chan EY, Longatti A, McKnight NC, Tooze SA (2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC 2612494. PMID 18936157.
• Ganley IG, Lam du H, Wang J; et al. (2009). "ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy". J. Biol. Chem. 284 (18): 12297–305. doi:10.1074/jbc.M900573200. PMC 2673298. PMID 19258318.
• Sinzelle L, Kapitonov VV, Grzela DP; et al. (2008). "Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes". Proc. Natl. Acad. Sci. U.S.A. 105 (12): 4715–20. doi:10.1073/pnas.0707746105. PMC 2290759. PMID 18339812.