ULK1

Unc-51 like autophagy activating kinase 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4WNO​, 4WNP​
Identifiers
Symbols	ULK1 ; ATG1; ATG1A; UNC51; Unc51.1; hATG1
External IDs	OMIM: 603168 MGI: 1270126 HomoloGene: 2640 ChEMBL: 6006 GeneCards: ULK1 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • protein binding • ATP binding • Rab GTPase binding • protein complex binding Cellular component • pre-autophagosomal structure • cytoplasm • autophagosome • cytosol • pre-autophagosomal structure membrane • extrinsic component of omegasome membrane • extrinsic component of pre-autophagosomal structure membrane • extrinsic component of autophagosome membrane • ATG1/UKL1 kinase complex Biological process • autophagosome assembly • protein phosphorylation • signal transduction • protein localization • regulation of autophagy • positive regulation of autophagy • positive regulation of macroautophagy • peptidyl-serine phosphorylation • neuron projection regeneration • neuron projection development • negative regulation of protein complex assembly • cellular response to nutrient levels • response to starvation • protein autophosphorylation • axon extension Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8408	22241
Ensembl	ENSG00000177169	ENSMUSG00000029512
UniProt	O75385	O70405
RefSeq (mRNA)	NM_003565	NM_009469
RefSeq (protein)	NP_003556	NP_033495
Location (UCSC)	Chr 12: 131.89 – 131.92 Mb	Chr 5: 110.78 – 110.81 Mb
PubMed search

Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene.^[1][2]

Function

ULK1 is an important protein in autophagy. It is part of the ULK1-complex, which is needed in early steps of autophagosome biogenesis.

Interactions

ULK1 has been shown to interact with GABARAPL2,^[3] GABARAP,^[3][4] SYNGAP1^[5] and SDCBP.^[5]

References

1. Kuroyanagi H, Yan J, Seki N, Yamanouchi Y, Suzuki Y, Takano T, Muramatsu M, Shirasawa T (Jul 1998). "Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment". Genomics 51 (1): 76–85. doi:10.1006/geno.1998.5340. PMID 9693035.
2. "Entrez Gene: ULK1 unc-51-like kinase 1 (C. elegans)".
3. Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research 85 (1-2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID 11146101.
4. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
5. Tomoda T, Kim JH, Zhan C, Hatten ME (Mar 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes & Development 18 (5): 541–58. doi:10.1101/gad.1151204. PMC 374236. PMID 15014045.

Further reading

• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research 85 (1-2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID 11146101.
• Tomoda T, Kim JH, Zhan C, Hatten ME (Mar 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes & Development 18 (5): 541–58. doi:10.1101/gad.1151204. PMC 374236. PMID 15014045.
• Young AR, Chan EY, Hu XW, Köchl R, Crawshaw SG, High S, Hailey DW, Lippincott-Schwartz J, Tooze SA (Sep 2006). "Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes". Journal of Cell Science 119 (Pt 18): 3888–900. doi:10.1242/jcs.03172. PMID 16940348.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (Mar 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Molecular & Cellular Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Chan EY, Kir S, Tooze SA (Aug 2007). "siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy". The Journal of Biological Chemistry 282 (35): 25464–74. doi:10.1074/jbc.M703663200. PMID 17595159.