GABARAPL2

GABA(A) receptor-associated protein like 2
PDB rendering based on 1eo6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4CO7​
Identifiers
Symbols	GABARAPL2 ; ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2
External IDs	OMIM: 607452 MGI: 1890602 HomoloGene: 68550 GeneCards: GABARAPL2 Gene
Gene ontology Molecular function • SNARE binding • protein binding • microtubule binding • ubiquitin protein ligase binding • beta-tubulin binding • GABA receptor binding • ATPase binding Cellular component • Golgi membrane • pre-autophagosomal structure • autophagosome membrane • intracellular • cytoplasm • autophagosome • Golgi apparatus • cytosol • extrinsic component of membrane • cytoplasmic vesicle Biological process • autophagosome assembly • mitophagy • intra-Golgi vesicle-mediated transport • autophagy • cellular response to nitrogen starvation • protein transport • positive regulation of ATPase activity • nucleophagy • membrane fusion • negative regulation of proteasomal protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11345	93739
Ensembl	ENSG00000034713	ENSMUSG00000031950
UniProt	P60520	P60521
RefSeq (mRNA)	NM_007285	NM_026693
RefSeq (protein)	NP_009216	NP_080969
Location (UCSC)	Chr 16: 75.57 – 75.58 Mb	Chr 8: 111.94 – 111.95 Mb
PubMed search

Gamma-aminobutyric acid receptor-associated protein-like 2 is a protein that in humans is encoded by the GABARAPL2 gene.^[1][2]

Interactions

GABARAPL2 has been shown to interact with ULK1,^[3] ATG4B,^[4][5] and FAM134B.^[6]

References

1. Xin Y, Yu L, Chen Z, Zheng L, Fu Q, Jiang J, Zhang P, Gong R, Zhao S (Jun 2001). "Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein". Genomics 74 (3): 408–13. doi:10.1006/geno.2001.6555. PMID 11414770.
2. "Entrez Gene: GABARAPL2 GABA(A) receptor-associated protein-like 2".
3. Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research 85 (1-2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID 11146101.
4. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
5. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
6. Khaminets, Aliaksandr; Heinrich, Theresa; Mari, Muriel; Grumati, Paolo; Huebner, Antje K.; Akutsu, Masato; Liebmann, Lutz; Stolz, Alexandra; Nietzsche, Sandor (2015-06-18). "Regulation of endoplasmic reticulum turnover by selective autophagy". Nature 522 (7556): 354–358. doi:10.1038/nature14498. ISSN 0028-0836.

Further reading

• Rohwer A, Kittstein W, Marks F, Gschwendt M (Jul 1999). "Cloning, expression and characterization of an A6-related protein". European Journal of Biochemistry / FEBS 263 (2): 518–25. doi:10.1046/j.1432-1327.1999.00537.x. PMID 10406962.
• Sagiv Y, Legesse-Miller A, Porat A, Elazar Z (Apr 2000). "GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28". The EMBO Journal 19 (7): 1494–504. doi:10.1093/emboj/19.7.1494. PMC 310219. PMID 10747018.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research 85 (1-2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID 11146101.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Tanida I, Tanida-Miyake E, Nishitani T, Komatsu M, Yamazaki H, Ueno T, Kominami E (Mar 2002). "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs". Biochemical and Biophysical Research Communications 292 (1): 256–62. doi:10.1006/bbrc.2002.6645. PMID 11890701.
• Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (Apr 2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". The Journal of Biological Chemistry 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID 12473658.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Sou YS, Tanida I, Komatsu M, Ueno T, Kominami E (Feb 2006). "Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16". The Journal of Biological Chemistry 281 (6): 3017–24. doi:10.1074/jbc.M505888200. PMID 16303767.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.