BCAP31

B-cell receptor-associated protein 31
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4JZL​, 4JZP​
Identifiers
Symbols	BCAP31 ; 6C6-AG; BAP31; CDM; DDCH; DXS1357E
External IDs	OMIM: 300398 MGI: 1350933 HomoloGene: 38095 GeneCards: BCAP31 Gene
Gene ontology Molecular function • protein binding • protein complex binding • MHC class I protein binding Cellular component • mitochondrion • endoplasmic reticulum • Sec61 translocon complex • endoplasmic reticulum membrane • lipid particle • cytosol • integral component of plasma membrane • membrane • clathrin-coated vesicle • Golgi cisterna membrane • endoplasmic reticulum-Golgi intermediate compartment membrane • integral component of lumenal side of endoplasmic reticulum membrane Biological process • antigen processing and presentation of peptide antigen via MHC class I • intracellular protein transport • ER to Golgi vesicle-mediated transport • apoptotic process • cellular component disassembly involved in execution phase of apoptosis • positive regulation of cytosolic calcium ion concentration • spermatogenesis • programmed cell death • negative regulation of endoplasmic reticulum calcium ion concentration • calcium-mediated signaling using intracellular calcium source • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of mitochondrial calcium ion concentration • protein localization to endoplasmic reticulum exit site • positive regulation of ER-associated ubiquitin-dependent protein catabolic process • positive regulation of retrograde protein transport, ER to cytosol • positive regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10134	27061
Ensembl	ENSG00000185825	ENSMUSG00000002015
UniProt	P51572	Q61335
RefSeq (mRNA)	NM_001139441	NM_012060
RefSeq (protein)	NP_001132913	NP_036190
Location (UCSC)	Chr X: 153.7 – 153.72 Mb	Chr X: 73.69 – 73.72 Mb
PubMed search

B-cell receptor-associated protein 31 is a protein that in humans is encoded by the BCAP31 gene.^[1]

Interactions

BCAP31 has been shown to interact with:

• APP,^[2]
• BCL2L1,^[3]
• BCL2,^[3]
• CASP8,^[3] and
• VAMP3.^[4]

References

1. "Entrez Gene: BCAP31 B-cell receptor-associated protein 31".
2. Wang B, Nguyen M, Breckenridge DG, Stojanovic M, Clemons PA, Kuppig S, Shore GC (Apr 2003). "Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria". J. Biol. Chem. 278 (16): 14461–8. doi:10.1074/jbc.M209684200. PMID 12529377.
3. Ng FW, Nguyen M, Kwan T, Branton PE, Nicholson DW, Cromlish JA, Shore GC (Oct 1997). "p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum". J. Cell Biol. 139 (2): 327–38. doi:10.1083/jcb.139.2.327. PMC 2139787. PMID 9334338.
4. Annaert WG, Becker B, Kistner U, Reth M, Jahn R (Dec 1997). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31". J. Cell Biol. 139 (6): 1397–410. doi:10.1083/jcb.139.6.1397. PMC 2132629. PMID 9396746.

Further reading

• Mosser J, Sarde CO, Vicaire S; et al. (1995). "A new human gene (DXS1357E) with ubiquitous expression, located in Xq28 adjacent to the adrenoleukodystrophy gene.". Genomics 22 (2): 469–71. doi:10.1006/geno.1994.1413. PMID 7806238.
• Sora I, Richman J, Santoro G; et al. (1994). "The cloning and expression of a human creatine transporter.". Biochem. Biophys. Res. Commun. 204 (1): 419–27. doi:10.1006/bbrc.1994.2475. PMID 7945388.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Adachi T, Schamel WW, Kim KM; et al. (1996). "The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence.". EMBO J. 15 (7): 1534–41. PMC 450061. PMID 8612576.
• Li E, Bestagno M, Burrone O (1996). "Molecular cloning and characterization of a transmembrane surface antigen in human cells.". Eur. J. Biochem. 238 (3): 631–8. doi:10.1111/j.1432-1033.1996.0631w.x. PMID 8706661.
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.". Genomics 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
• Ng FW, Nguyen M, Kwan T; et al. (1997). "p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum.". J. Cell Biol. 139 (2): 327–38. doi:10.1083/jcb.139.2.327. PMC 2139787. PMID 9334338.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Annaert WG, Becker B, Kistner U; et al. (1998). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31.". J. Cell Biol. 139 (6): 1397–410. doi:10.1083/jcb.139.6.1397. PMC 2132629. PMID 9396746.
• Nguyen M, Breckenridge DG, Ducret A, Shore GC (2000). "Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria.". Mol. Cell. Biol. 20 (18): 6731–40. doi:10.1128/MCB.20.18.6731-6740.2000. PMC 86192. PMID 10958671.
• Bell AW, Ward MA, Blackstock WP; et al. (2001). "Proteomics characterization of abundant Golgi membrane proteins.". J. Biol. Chem. 276 (7): 5152–65. doi:10.1074/jbc.M006143200. PMID 11042173.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Spiliotis ET, Manley H, Osorio M; et al. (2001). "Selective export of MHC class I molecules from the ER after their dissociation from TAP.". Immunity 13 (6): 841–51. doi:10.1016/S1074-7613(00)00081-9. PMID 11163199.
• Manley HA, Lennon VA (2001). "Endoplasmic reticulum membrane-sorting protein of lymphocytes (BAP31) is highly expressed in neurons and discrete endocrine cells.". J. Histochem. Cytochem. 49 (10): 1235–43. doi:10.1177/002215540104901005. PMID 11561007.
• Zuppini A, Groenendyk J, Cormack LA; et al. (2002). "Calnexin deficiency and endoplasmic reticulum stress-induced apoptosis.". Biochemistry 41 (8): 2850–8. doi:10.1021/bi015967. PMID 11851433.
• Breckenridge DG, Nguyen M, Kuppig S; et al. (2002). "The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4331–6. doi:10.1073/pnas.072088099. PMC 123648. PMID 11917123.
• Corzo D, Gibson W, Johnson K; et al. (2002). "Contiguous deletion of the X-linked adrenoleukodystrophy gene (ABCD1) and DXS1357E: a novel neonatal phenotype similar to peroxisomal biogenesis disorders.". Am. J. Hum. Genet. 70 (6): 1520–31. doi:10.1086/340849. PMC 419992. PMID 11992258.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang B, Nguyen M, Breckenridge DG; et al. (2003). "Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria.". J. Biol. Chem. 278 (16): 14461–8. doi:10.1074/jbc.M209684200. PMID 12529377.
• Mund T, Gewies A, Schoenfeld N; et al. (2003). "Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum.". FASEB J. 17 (6): 696–8. doi:10.1096/fj.02-0657fje. PMID 12594175.

External links

• BCAP31 human gene location in the UCSC Genome Browser.
• BCAP31 human gene details in the UCSC Genome Browser.