BCL2L11

BCL2-like 11 (apoptosis facilitator)
Rendering based on PDB 2K7W​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1F95​, 2K7W​, 2NL9​, 2V6Q​, 2VM6​, 2WH6​, 2YQ6​, 2YQ7​, 3D7V​, 3FDL​, 3IO8​, 3IO9​, 3KJ0​, 3KJ1​, 3KJ2​, 4A1U​, 4A1W​, 4B4S​, 4D2M​
Identifiers
Symbols	BCL2L11 ; BAM; BIM; BOD
External IDs	OMIM: 603827 MGI: 1197519 HomoloGene: 7643 ChEMBL: 5777 GeneCards: BCL2L11 Gene
Gene ontology Molecular function • protein binding • microtubule binding Cellular component • mitochondrion • mitochondrial outer membrane • cytosol • microtubule • endomembrane system • extrinsic component of membrane • BIM-BCL-xl complex • BIM-BCL-2 complex Biological process • in utero embryonic development • B cell homeostasis • B cell apoptotic process • kidney development • myeloid cell homeostasis • apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • meiosis I • cell-matrix adhesion • spermatogenesis • brain development • male gonad development • intrinsic apoptotic signaling pathway in response to DNA damage • programmed cell death • mammary gland development • positive regulation of protein homooligomerization • response to endoplasmic reticulum stress • tube formation • odontogenesis of dentin-containing tooth • T cell homeostasis • positive regulation of apoptotic process • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of neuron apoptotic process • ear development • positive regulation of cell cycle • regulation of organ growth • neurotrophin TRK receptor signaling pathway • developmental pigmentation • regulation of developmental pigmentation • spleen development • thymus development • post-embryonic organ morphogenesis • positive regulation of apoptotic process by virus • cellular process regulating host cell cycle in response to virus • thymocyte apoptotic process • positive regulation of release of cytochrome c from mitochondria • apoptotic signaling pathway • extrinsic apoptotic signaling pathway in absence of ligand • intrinsic apoptotic signaling pathway • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of mitochondrial membrane permeability involved in apoptotic process • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • apoptotic process involved in embryonic digit morphogenesis • positive regulation of IRE1-mediated unfolded protein response • positive regulation of fibroblast apoptotic process • positive regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10018	12125
Ensembl	ENSG00000153094	ENSMUSG00000027381
UniProt	O43521	O54918
RefSeq (mRNA)	NM_001204106	NM_001284410
RefSeq (protein)	NP_001191035	NP_001271339
Location (UCSC)	Chr 2: 111.12 – 111.17 Mb	Chr 2: 128.13 – 128.16 Mb
PubMed search

Bcl-2-like protein 11, commonly called BIM, is a protein that in humans is encoded by the BCL2L11 gene.^[1][2]

Function

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1 (FoxO3a), which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.^[3]

Interactions

BCL2L11 has been shown to interact with:

• BCL2-like 1,^[1][2][4][5]
• BCL2L2,^[1][2]
• Bcl-2,^[1][2][4]
• DYNLL1,^[6][7] and
• MCL1.^[1][4][8]

See also

• Bcl-2

References

1. Hsu SY, Lin P, Hsueh AJ (November 1998). "BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members". Mol Endocrinol 12 (9): 1432–40. doi:10.1210/mend.12.9.0166. PMID 9731710.
2. O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC (February 1998). "Bim: a novel member of the Bcl-2 family that promotes apoptosis". EMBO J 17 (2): 384–95. doi:10.1093/emboj/17.2.384. PMC 1170389. PMID 9430630.
3. "Entrez Gene: BCL2L11 BCL2-like 11 (apoptosis facilitator)".
4. Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
5. Whitfield J, Harada K, Bardelle C, Staddon JM (November 2003). "High-throughput methods to detect dimerization of Bcl-2 family proteins". Anal. Biochem. 322 (2): 170–8. doi:10.1016/j.ab.2003.07.014. PMID 14596824.
6. Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC, Hinds MG (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.
7. Vadlamudi RK, Bagheri-Yarmand R, Yang Z, Balasenthil S, Nguyen D, Sahin AA, den Hollander P, Kumar R (June 2004). "Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes". Cancer Cell 5 (6): 575–85. doi:10.1016/j.ccr.2004.05.022. PMID 15193260.
8. Bae J, Leo CP, Hsu SY, Hsueh AJ (August 2000). "MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain". J. Biol. Chem. 275 (33): 25255–61. doi:10.1074/jbc.M909826199. PMID 10837489.

Further reading

• Wang K, Yin XM, Chao DT; et al. (1996). "BID: a novel BH3 domain-only death agonist". Genes Dev. 10 (22): 2859–69. doi:10.1101/gad.10.22.2859. PMID 8918887.
• Zha J, Harada H, Yang E; et al. (1997). "Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)". Cell 87 (4): 619–28. doi:10.1016/S0092-8674(00)81382-3. PMID 8929531.
• Huang DC, Adams JM, Cory S (1998). "The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4". EMBO J. 17 (4): 1029–39. doi:10.1093/emboj/17.4.1029. PMC 1170452. PMID 9463381.
• Puthalakath H, Huang DC, O'Reilly LA; et al. (1999). "The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex". Mol. Cell 3 (3): 287–96. doi:10.1016/S1097-2765(00)80456-6. PMID 10198631.
• Ohi N, Tokunaga A, Tsunoda H; et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region". Cell Death Differ. 6 (4): 314–25. doi:10.1038/sj.cdd.4400493. PMID 10381623.
• Bouillet P, Metcalf D, Huang DC; et al. (1999). "Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity". Science 286 (5445): 1735–8. doi:10.1126/science.286.5445.1735. PMID 10576740.
• Bae J, Leo CP, Hsu SY, Hsueh AJ (2000). "MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain". J. Biol. Chem. 275 (33): 25255–61. doi:10.1074/jbc.M909826199. PMID 10837489.
• Dijkers PF, Medema RH, Lammers JW; et al. (2000). "Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1". Curr. Biol. 10 (19): 1201–4. doi:10.1016/S0960-9822(00)00728-4. PMID 11050388.
• Bouillet P, Zhang LC, Huang DC; et al. (2001). "Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim". Mamm. Genome 12 (2): 163–8. doi:10.1007/s003350010242. PMID 11210187.
• Putcha GV, Moulder KL, Golden JP; et al. (2001). "Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis". Neuron 29 (3): 615–28. doi:10.1016/S0896-6273(01)00238-0. PMID 11301022.
• Murray S, Halford S, Ebenezer ND; et al. (2001). "Assignment of BCL2L11 to human chromosome band 2p13 with somatic cell and radiation hybrids". Cytogenet. Cell Genet. 92 (3–4): 353. doi:10.1159/000056930. PMID 11435715.
• Cheng EH, Wei MC, Weiler S; et al. (2001). "BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis". Mol. Cell 8 (3): 705–11. doi:10.1016/S1097-2765(01)00320-3. PMID 11583631.
• U M, Miyashita T, Shikama Y; et al. (2002). "Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family". FEBS Lett. 509 (1): 135–41. doi:10.1016/S0014-5793(01)03145-3. PMID 11734221.
• Bouillet P, Purton JF, Godfrey DI; et al. (2002). "BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes". Nature 415 (6874): 922–6. doi:10.1038/415922a. PMID 11859372.
• Marani M, Tenev T, Hancock D; et al. (2002). "Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis". Mol. Cell. Biol. 22 (11): 3577–89. doi:10.1128/MCB.22.11.3577-3589.2002. PMC 133811. PMID 11997495.
• Liu JW, Chandra D, Tang SH; et al. (2002). "Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim". Cancer Res. 62 (10): 2976–81. PMID 12019181.
• Terradillos O, Montessuit S, Huang DC, Martinou JC (2002). "Direct addition of BimL to mitochondria does not lead to cytochrome c release". FEBS Lett. 522 (1–3): 29–34. doi:10.1016/S0014-5793(02)02871-5. PMID 12095614.
• Sugiyama T, Shimizu S, Matsuoka Y; et al. (2002). "Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim". Oncogene 21 (32): 4944–56. doi:10.1038/sj.onc.1205621. PMID 12118373.

External links

• BCL2L11 human gene location in the UCSC Genome Browser.
• BCL2L11 human gene details in the UCSC Genome Browser.