Biliverdin reductase A

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2H63

Identifiers

Symbols

BLVRA ; BLVR; BVR; BVRA

External IDs

OMIM: 109750 HomoloGene: 572 GeneCards: BLVRA Gene

EC number

1.3.1.24

Gene ontology
Molecular function	• biliverdin reductase activity • protein binding • zinc ion binding
Cellular component	• cytosol • extracellular exosome
Biological process	• porphyrin-containing compound metabolic process • heme catabolic process • small molecule metabolic process • oxidation-reduction process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

644

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
43.76 – 43.81 Mb

Chr 2:
127.07 – 127.1 Mb

PubMed search

Biliverdin reductase A is a protein that in humans is encoded by the BLVRA gene.^[1]

Function

The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH.^[1]

Clinical significance

Mutations in this gene are associated with hyperbiliverdinemia.^[1]

References

1 2 3 "Entrez Gene: Biliverdin reductase A".

Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase

1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD

1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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