BNIP3L

BCL2/adenovirus E1B 19kDa interacting protein 3-like
Identifiers
Symbols	BNIP3L ; BNIP3a; NIX
External IDs	OMIM: 605368 MGI: 1332659 HomoloGene: 3195 GeneCards: BNIP3L Gene
Gene ontology Molecular function • protein binding • lamin binding • identical protein binding • protein homodimerization activity • protein heterodimerization activity Cellular component • nuclear envelope • mitochondrion • mitochondrial outer membrane • endoplasmic reticulum • integral component of membrane • intrinsic component of membrane Biological process • viral process • mitochondrial protein catabolic process • positive regulation of apoptotic process • negative regulation of apoptotic process • defense response to virus • mitochondrial outer membrane permeabilization • regulation of mitophagy • regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	665	12177
Ensembl	ENSG00000104765	ENSMUSG00000022051
UniProt	O60238	Q9Z2F7
RefSeq (mRNA)	NM_004331	NM_009761
RefSeq (protein)	NP_004322	NP_033891
Location (UCSC)	Chr 8: 26.38 – 26.51 Mb	Chr 14: 66.99 – 67.01 Mb
PubMed search

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like is a protein that in humans is encoded by the BNIP3L gene.^[1][2][3]

Function

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This protein may function simultaneously with BNIP3 and may play a role in tumor suppression.^[3]

Interactions

BNIP3L has been shown to interact with STEAP3.^[4]

References

1. Matsushima M, Fujiwara T, Takahashi E, Minaguchi T, Eguchi Y, Tsujimoto Y, Suzumori K, Nakamura Y (May 1998). "Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3". Genes Chromosomes Cancer 21 (3): 230–5. doi:10.1002/(SICI)1098-2264(199803)21:3<230::AID-GCC7>3.0.CO;2-0. PMID 9523198.
2. Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G (Feb 1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3". Cancer Res 59 (3): 533–7. PMID 9973195.
3. "Entrez Gene: BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like".
4. Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A (Mar 2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMC 151332. PMID 12606722.

Further reading

• Chen G, Cizeau J, Vande Velde C, Park JH, Bozek G, Bolton J, Shi L, Dubik D, Greenberg A (1999). "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins.". J. Biol. Chem. 274 (1): 7–10. doi:10.1074/jbc.274.1.7. PMID 9867803.
• Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K, Motoyama N, Nakajima T (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.". Cell Death Differ. 6 (4): 314–25. doi:10.1038/sj.cdd.4400493. PMID 10381623.
• Imazu T, Shimizu S, Tagami S, Matsushima M, Nakamura Y, Miki T, Okuyama A, Tsujimoto Y (1999). "Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability.". Oncogene 18 (32): 4523–9. doi:10.1038/sj.onc.1202722. PMID 10467396.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A (2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMC 151332. PMID 12606722.
• Aerbajinai W, Giattina M, Lee YT, Raffeld M, Miller JL (2003). "The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation.". Blood 102 (2): 712–7. doi:10.1182/blood-2002-11-3324. PMID 12663450.
• Sun JL, He XS, Yu YH, Chen ZC (2004). "[Expression and structure of BNIP3L in lung cancer]". Ai Zheng 23 (1): 8–14. PMID 14720367.
• Fei P, Wang W, Kim SH, Wang S, Burns TF, Sax JK, Buzzai M, Dicker DT, McKenna WG, Bernhard EJ, El-Deiry WS (2005). "Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth.". Cancer Cell 6 (6): 597–609. doi:10.1016/j.ccr.2004.10.012. PMID 15607964.
• Stepan H, Leo C, Purz S, Höckel M, Horn LC (2006). "Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome.". Eur. J. Obstet. Gynecol. Reprod. Biol. 122 (2): 172–6. doi:10.1016/j.ejogrb.2005.01.017. PMID 16219518.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.