STEAP3

STEAP family member 3, metalloreductase
Rendering based on PDB 2VNS​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2VNS​, 2VQ3​
Identifiers
Symbols	STEAP3 ; AHMIO2; STMP3; TSAP6; dudlin-2; dudulin-2; pHyde
External IDs	OMIM: 609671 MGI: 1915678 HomoloGene: 10084 GeneCards: STEAP3 Gene
EC number	1.16.1.-
Gene ontology Molecular function • protein binding • cupric reductase activity • metal ion binding • ferric-chelate reductase (NADPH) activity Cellular component • multivesicular body • integral component of plasma membrane • endosome membrane Biological process • cellular iron ion homeostasis • apoptotic process • cell cycle • protein secretion • copper ion import • transferrin transport • positive regulation of apoptotic process • transmembrane transport • oxidation-reduction process • ferric iron import into cell Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55240	68428
Ensembl	ENSG00000115107	ENSMUSG00000026389
UniProt	Q658P3	Q8CI59
RefSeq (mRNA)	NM_001008410	NM_001085409
RefSeq (protein)	NP_001008410	NP_001078878
Location (UCSC)	Chr 2: 119.22 – 119.27 Mb	Chr 1: 120.19 – 120.27 Mb
PubMed search

Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene.^[1][2]

STEAP3 is a metalloreductase, capable of coverting iron from an insoluble ferric (Fe³⁺) to a soluble ferrous (Fe²⁺) form.^[3]

Interactions

STEAP3 has been shown to interact with BNIP3L^[1] and PKMYT1.^[1]

References

1. Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A (Mar 2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proc Natl Acad Sci U S A 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMC 151332. PMID 12606722.
2. "Entrez Gene: STEAP3 STEAP family member 3".
3. Ohgami RS, Campagna DR, McDonald A, Fleming MD (August 2006). "The Steap proteins are metalloreductases". Blood 108 (4): 1388–94. doi:10.1182/blood-2006-02-003681. PMC 1785011. PMID 16609065.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer.". J. Biol. Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.
• Amzallag N, Passer BJ, Allanic D, Segura E, Théry C, Goud B, Amson R, Telerman A (2004). "TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway.". J. Biol. Chem. 279 (44): 46104–12. doi:10.1074/jbc.M404850200. PMID 15319436.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.