Basophilia

Basophilia
Classification and external resources
Specialty	hematology
ICD-10	D75.8
ICD-9-CM	288.65
DiseasesDB	29698

Basophilia is a condition where the basophil quantity is abnormally elevated (more than 10¹⁰ basophils per liter of blood).^[1] Basophilia is associated with Pruritis (itching) due to the basophils release of histamine.^[2]

Causes

Basophilia as an isolated finding is uncommon. However it is a common feature of myeloproliferative disorders and particularly prominent in chronic myelogenous leukemia.^[3][4]

Conditions Associated with Alterations in Numbers of Blood Basophils

I. Decreased Numbers (Basopenia)

 A. Hereditary absence of basophils (very rare)
 B. Elevated levels of glucocorticoids
 C. Hyperthyroidism or treatment with thyroid hormones
 D. Ovulation
 E. Hypersensitivity reactions
   1. Urticaria
   2. Anaphylaxis
   3. Drug-induced reactions
 F. Leukocytosis (in association with diverse disorders)

II. Increased Numbers (Basophilia)

 A. Allergy or inflammation
   1. Ulcerative colitis
   2. Drug, food, inhalant hypersensitivity
   3. Erythroderma, urticaria
   4. Juvenile rheumatoid arthritis
 B. Endocrinopathy
   1. Diabetes mellitus
   2. Estrogen administration
   3. Hypothyroidism (myxedema)
 C. Infection
   1. Chicken pox
   2. Influenza
   3. Smallpox
   4. Tuberculosis
 D. Iron deficiency
 E. Exposure to ionizing radiation
 F. Neoplasia
   1. "Basophilic leukemia" (see text)
 G. Myeloproliferative neoplasms (especially chronic myelogenous leukemia; also polycythemia vera, primary myelofibrosis, essential thrombocythemia)
 H. Carcinoma

References

1. "Cytoplasmic basophilia". Veterinary Clinical Pathology Image Database. University of Montreal Veterinary College. Retrieved 2008-09-20.
2. Interactive, Wellfire. "Pathology Thread". www.med-ed.virginia.edu. Retrieved 2016-04-07.
3. Ravandi, F.; R. Hoffman (2005). "Chapter 17. Phagocytes". In A.V. Hoffbrand; et al. Postgraduate Haematology. Boston: Blackwell Publishing. pp. 296–298. ISBN 1-4051-0821-5.
4. Table 12-6 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.