Beta-amyrin 11-oxidase

Beta-amyrin 11-oxidase
Identifiers
EC number	1.14.13.134
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Beta-amyrin 11-oxidase (EC 1.14.13.134, CYP88D6) is an enzyme with systematic name beta-amyrin,NADPH:oxygen oxidoreductase (hydroxylating).^[1] This enzyme catalyses the following chemical reaction

beta-amyrin + 2 O₂ + 2 NADPH + 2 H⁺ $\rightleftharpoons$ 11-oxo-beta-amyrin + 3 H₂O + 2 NADP⁺ (overall reaction)

(1a) beta-amyrin + O₂ + NADPH + H⁺ $\rightleftharpoons$ 11alpha-hydroxy-beta-amyrin + H₂O + NADP⁺

(1b) 11alpha-hydroxy-beta-amyrin + O₂ + NADPH + H⁺ $\rightleftharpoons$ 11-oxo-beta-amyrin + 2 H₂O + NADP⁺

Beta-amyrin 11-oxidase requires cytochrome P450.

References

1. Seki, H., Ohyama, K., Sawai, S., Mizutani, M., Ohnishi, T., Sudo, H., Akashi, T., Aoki, T., Saito, K. and Muranaka, T. (2008). "Licorice β-amyrin 11-oxidase, a cytochrome P₄₅₀ with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin". Proc. Natl. Acad. Sci. USA 105 (37): 14204–14209. doi:10.1073/pnas.0803876105. PMC 2532699. PMID 18779566.

External links

• Beta-amyrin 11-oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)