Bicoid 3'-UTR regulatory element
| Bicoid 3'-UTR regulatory element | |
|---|---|
 | |
| Stem-loop structure of the bicoid 3'-UTR regulatory element | |
| Identifiers | |
| Symbol | bcd |
| Rfam | RF00551 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Insecta |
The bicoid 3'-UTR regulatory element is an mRNA regulatory element that controls the gene expression of the bicoid protein in fruitfly Drosophila Melanogaster.
The structured RNA element consists of four domains (denoted as II, III, IV and V) in the 3'UTR of the mRNA. It is essential for the correct transport and localisation of bicoid mRNA during oocyte and embryo differentiation, which has been studied most thoroughly in the development of Drosophila melanogaster (fruitfly) larvae.[1][2][3][4]
References
- ↑ Macdonald PM, Struhl G (1988). "cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos.". Nature 336 (6199): 595–8. doi:10.1038/336595a0. PMID 3143913.
- ↑ MacDonald PM (1990). "bicoid mRNA localization signal: phylogenetic conservation of function and RNA secondary structure.". Development 110 (1): 161–71. PMID 2081457.
- ↑ Seeger MA, Kaufman TC (1990). "Molecular analysis of the bicoid gene from Drosophila pseudoobscura: identification of conserved domains within coding and noncoding regions of the bicoid mRNA.". EMBO J 9 (9): 2977–87. PMC 552015. PMID 1975239.
- ↑ Ehresmann C, C; Ehresmann, C (2004). "Secondary structure of the 3' UTR of bicoid mRNA". Biochimie 86 (2): 91–104. doi:10.1016/j.biochi.2004.01.002. PMID 15016447.
External links
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