Biotin—(methylmalonyl-CoA-carboxytransferase) ligase

The 3 substrates of this enzyme are ATP, biotin, and [[apo-[methylmalonyl-CoA:pyruvate carboxytransferase]]], whereas its 3 products are AMP, diphosphate, and methylmalonyl-CoA:pyruvate carboxytransferase.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo[methylmalonyl-CoA:pyruvate carboxytransferase] ligase (AMP-forming). Other names in common use include biotin-[methylmalonyl-CoA-carboxyltransferase] synthetase, biotin-methylmalonyl coenzyme A carboxyltransferase synthetase, biotin-transcarboxylase synthetase, methylmalonyl coenzyme A holotranscarboxylase synthetase, biotin-[methylmalonyl-CoA-carboxyltransferase] ligase, biotin:apo[methylmalonyl-CoA:pyruvate carboxyltransferase] ligase, and (AMP-forming). This enzyme participates in biotin metabolism.

References

Lane MD, Young DL and Lynen F (1964). "The enzymatic synthesis of holotranscarboxylase from apotranscarboxylase and (+)-biotin. I. Purification of the apoenzyme and synthetase; characteristics of the reaction". J. Biol. Chem. 239: 2858–2864.

Enzymes: CO CS and CN ligases (EC 6.1-6.3)

6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine

6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase

6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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