Botryococcene C-methyltransferase

Botryococcene C-methyltransferase
Identifiers
EC number	2.1.1.263
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Botryococcene C-methyltransferase (EC 2.1.1.263, TMT-3) is an enzyme with systematic name S-adenosyl-L-methionine:botryococcene C-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + C30 botryococcene $\rightleftharpoons$ 2 S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene (overall reaction)

(1a) S-adenosyl-L-methionine + C30 botryococcene $\rightleftharpoons$ S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene

(1b) S-adenosyl-L-methionine + 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene $\rightleftharpoons$ S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene

(2a) S-adenosyl-L-methionine + C30 botryococcene $\rightleftharpoons$ S-adenosyl-L-homocysteine + 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene

(2b) S-adenosyl-L-methionine + 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene $\rightleftharpoons$ S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene

This enzyme is isolated from the green alga Botryococcus braunii BOT22.

References

1. Niehaus, T.D., Kinison, S., Okada, S., Yeo, Y.S., Bell, S.A., Cui, P., Devarenne, T.P. and Chappell, J. (2012). "Functional identification of triterpene methyltransferases from Botryococcus braunii race B". J. Biol. Chem. 287: 8163–8173. doi:10.1074/jbc.m111.316059. PMID 22241476.

External links

• Botryococcene C-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)