Bromide peroxidase

Bromide peroxidase (EC 1.11.1.18, bromoperoxidase, haloperoxidase (ambiguous), eosinophil peroxidase) is an enzyme with systematic name bromide:hydrogen-peroxide oxidoreductase.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

RH + HBr + H₂O₂

\rightleftharpoons

RBr + 2 H₂O

Bromo peroxidases of red and brown marine algae (Rhodophyta and Phaeophyta) contain vanadate.

References

↑ De Boer, E., Tromp, M.G.M., Plat, H., Krenn, G.E. and Wever, R (1986). "Vanadium(v) as an essential element for haloperoxidase activity in marine brown-algae - purification and characterization of a vanadium(V)-containing bromoperoxidase from Laminaria saccharina". Biochim. Biophys. Acta 872: 104–115. doi:10.1016/0167-4838(86)90153-6.
↑ Tromp, M.G., Olafsson, G., Krenn, B.E. and Wever, R. (1990). "Some structural aspects of vanadium bromoperoxidase from Ascophyllum nodosum". Biochim. Biophys. Acta 1040 (2): 192–198. doi:10.1016/0167-4838(90)90075-q. PMID 2400770.
↑ Isupov, M.N., Dalby, A.R., Brindley, A.A., Izumi, Y., Tanabe, T., Murshudov, G.N. and Littlechild, J.A. (2000). "Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis". J. Mol. Biol. 299: 1035–1049. doi:10.1006/jmbi.2000.3806. PMID 10843856.
↑ Carter-Franklin, J.N. and Butler, A. (2004). "Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products". J. Am. Chem. Soc. 126: 15060–15066. doi:10.1021/ja047925p. PMID 15548002.
↑ Ohshiro, T., Littlechild, J., Garcia-Rodriguez, E., Isupov, M.N., Iida, Y., Kobayashi, T. and Izumi, Y. (2004). "Modification of halogen specificity of a vanadium-dependent bromoperoxidase". Protein Sci. 13: 1566–1571. doi:10.1110/ps.03496004. PMC 2279980. PMID 15133166.

External links

Bromide peroxidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: peroxidases (EC 1.11)

1.11.1.1-14	Catalase Cytochrome c peroxidase Eosinophil peroxidase Glutathione peroxidase GPX 1 2 3 4 5 6 7 8 Horseradish peroxidase Lactoperoxidase Myeloperoxidase Thyroid peroxidase Deiodinase Iodothyronine deiodinase Iodotyrosine deiodinase

1.11.1.15 (peroxiredoxin)	1 2 3 4 5 6

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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