C-ANCA

The granular, cytoplasmic staining pattern of c-ANCA

c-ANCAs, or PR3-ANCA, or Cytoplasmic antineutrophil cytoplasmic antibodies, are a type of autoantibody, an antibody produced by the body that acts against one of its own proteins. These antibodies show a diffusely granular, cytoplasmic staining pattern under microscopy. This pattern results from binding of ANCAs to antigen targets throughout the neutrophil cytoplasm, the most common protein target being proteinase 3 (PR3). For example, PR3 is the most common antigen target of ANCA in patients with granulomatosis with polyangiitis. In active granulomatosis with polyangiitis, c-ANCA is found over 90% of the time.^[1] Other antigens may also occasionally result in a c-ANCA pattern.

References

↑ Thomas M. Habermann (26 June 2006). Mayo Clinic internal medicine review, 2006-2007. CRC Press. pp. 935–. ISBN 978-0-8493-9059-3. Retrieved 1 November 2010.

Medical test: Antibodies: autoantibodies

Anti-nuclear antibody	PBC: Anti-gp210 Anti-p62 Anti-sp100 ENA: Anti-topoisomerase/Scl-70 Anti-Jo1 ENA4 Anti-Sm Anti-nRNP Anti-Ro Anti-La Anti-centromere Anti-dsDNA

Anti-mitochondrial antibody	Anti-cardiolipin

Anti-cytoplasm antibody	Anti-neutrophil cytoplasmic C-ANCA P-ANCA Anti-smooth muscle Anti-actin Anti-TPO/Antimicrosomal

Cell membrane	Anti-ganglioside Anti-GBM Anti-glutamate

Extracellular	Anti-thrombin Lupus anticoagulant Coeliac disease: Anti-transglutaminase Anti-gliadin not autoantibody RA Rheumatoid factor/anti-IgG Anti-citrullinated peptide

Multiple locations	Anti-phospholipid Anti-apolipoprotein

Systemic vasculitis (M30–M31, 446)

Large vessel

Medium vessel

Small vessel

Pauci-immune	c-ANCA Granulomatosis with polyangiitis p-ANCA Churg-Strauss syndrome Microscopic polyangiitis

Type III hypersensitivity	Hypersensitivity vasculitis/Henoch–Schönlein purpura

Ungrouped	Acute hemorrhagic edema of infancy Cryoglobulinemic vasculitis Bullous small vessel vasculitis Cutaneous small-vessel vasculitis

Other

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C-ANCA

See also

References