Anti-p62 antibodies

Autoantibody
Anti-p62
Autoantigen Isoform	Nucleoporin 62kDA
Autoantigen gene	NUP62
Affected organ(s)	Bile duct
Associated Disease(s)	Primary biliary cirrhosis
HLA associations	DR2 (weak)

Anti-p62 antibodies (AP62A) are found in a primary biliary cirrhosis.^[1] The p62 protein is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease.^[2][3] The autoantigen is the nucleoporin 62kDA protein.

References

1. Wesierska-Gadek J, Hohenuer H, Hitchman E, Penner E (1996). "Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis". Gastroenterology 110 (3): 840–7. doi:10.1053/gast.1996.v110.pm8608894. PMID 8608894.
2. Miyachi K, Hankins RW, Matsushima H; et al. (2003). "Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study". J. Autoimmun. 20 (3): 247–54. doi:10.1016/S0896-8411(03)00033-7. PMID 12753810.
3. Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J (2005). "Antinuclear antibodies in primary biliary cirrhosis". Semin. Liver Dis. 25 (3): 298–310. doi:10.1055/s-2005-916321. PMID 16143945.