HLA-DR2

HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.

Serology

DR15, DR2 and other serotype recognition of some DRB1*15 alleles^[1]

DRB1*	DR15	DR2	DR16	Sample
allele	%	%	%	size (N)
1501	76	23		6428
1502	77	16		676
1503	81	13		286
1504	>50			1
1505	>25			2
1507	>50			1
				.
	DR16	DR2	DR15	N
1601	41	29	19	703
1602	47	30	16	239
1604	>50			1

Disease associations

DR2 serotypes are associated with Goodpasture syndrome, systemic lupus erythematosus, multiple sclerosis,^[2] and narcolepsy, tuberculoid leprosy^[3] (multi-drug resistant tuberculosis or leprosy),^[4] ulcerative colitis(Japanese),^[5] primary biliary cirrhosis and autoimmune hepatitis.^[6] DR2 is also found in all patients that test positive for anti-anti-Asn-RNA-synthetase and chronic interstitial lung disease.^[7]

Genetic linkage

DR2 is linked to the HLA-DR53.

References

1. derived from IMGT/HLA
2. Stewart G, McLeod J, Basten A, Bashir H (1981). "HLA family studies and multiple sclerosis: A common gene, dominantly expressed.". Hum Immunol 3 (1): 13–29. doi:10.1016/0198-8859(81)90040-9. PMID 7275697.
3. van Eden W, de Vries R, Mehra N, Vaidya M, D'Amaro J, van Rood J (1980). "HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker.". J Infect Dis 141 (6): 693–701. doi:10.1093/infdis/141.6.693. PMID 6156220.
4. Singh M, Balamurugan A, Katoch K, Sharma SK, Mehra NK (2007). "Immunogenetics of mycobacterial infections in the North Indian population". Tissue Antigens. 69 Suppl 1: 228–30. doi:10.1111/j.1399-0039.2006.77311.x. PMID 17445206.
5. Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T, Ando K, Takata H, Sekiguchi S (1982). "Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis.". Gastroenterology 82 (3): 413–8. PMID 6947923.
6. Miyamori H, Kato Y, Kobayashi K, Hattori N (1983). "HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis.". Digestion 26 (4): 213–7. doi:10.1159/000198892. PMID 6409699.
7. Hirakata M, Suwa A, Takada T, et al. (2007). "Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase". Arthritis Rheum. 56 (4): 1295–303. doi:10.1002/art.22506. PMID 17393393.