HLA-DR8

human major histocompatibility complex, class II, DR8
Haplotypes groups	DQA*01:DRB1*0801 to DQA*01:DRB1*0806
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 *0801 to *0806
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*0801
EBI-HLA	DRB1*0802
EBI-HLA	DRB1*0803
EBI-HLA	DRB1*0804
EBI-HLA	DRB1*0805
EBI-HLA	DRB1*0806
Shared data
Locus	chr.6 6p21.31

HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.

Serology

DR8 serological recognition of the gene products of some DRB1*08 alleles^[1]

DRB1*	DR8	Sample
allele	%	size (N)
0801	95	1076
0802	96	265
0803	88	230[2]
0804	93	186
0805	>60	5
0806	>75	13

The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.

Disease associations

DQ8 is linked to papillary thyroid carcinomas,^[3] early onset pauciarticular juvenile chronic arthritis,^[4][5] primary biliary cirrhosis^[6]

by allele

HLA-DRB1*0801 is linked to primary biliary cirrhosis^[7] In Mexicans DR8 is found more often in type-2 juvenile diabetes.^[8]

HLA-DRB1*0803 is also linked to primary biliary cirrhosis^[7]

Genetic Linkage

DR8 Haplotypes
	DRA	DRB1
Haplotypes	*0101	*0801	*0101
	DQA1	DQB1	DRB1
Haplotypes	*0401	*0402	*0801
	HLA-A	HLA-B	DRB1
Haplotypes	*0000	*0000	*0801

HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.

References

1. derived from IMGT/HLA
2. DR12 - 3%
3. Porto T, Coelho I, Boavida J, Pereira C, Nunes J, Mendonça D, Martins B, Sobrinho L, Leite V (2006). "Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas.". Clin Endocrinol (Oxf) 64 (2): 179–83. doi:10.1111/j.1365-2265.2006.02445.x. PMID 16430717.
4. Haas J, Truckenbrodt H, Paul C, Hoza J, Scholz S, Albert E (1994). "Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis.". Clin Exp Rheumatol. 12 Suppl 10: S7–14. PMID 7955632.
5. Säilä H, Pitkäniemi J, Tuomilehto J, Savolainen A, Alakulppi N, Tuomilehto-Wolf E, Leirisalo-Repo M, Aho K (2004). "HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population.". J Rheumatol 31 (11): 2281–5. PMID 15517645.
6. Underhill J, Donaldson P, Bray G, Doherty D, Portmann B, Williams R (1992). "Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype.". Hepatology 16 (6): 1404–8. doi:10.1002/hep.1840160616. PMID 1359995.
7. Charatcharoenwitthaya P, Lindor K (2005). "Current concepts in the pathogenesis of primary biliary cirrhosis.". Ann Hepatol 4 (3): 161–75. PMID 16177655.
8. Rodríguez-Ventura AL, Yamamoto-Furusho JK, Coyote N, et al. (2007). "HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children". Pediatric Diabetes 8 (1): 5–10. doi:10.1111/j.1399-5448.2006.00221.x. PMID 17341285.