C-myc internal ribosome entry site (IRES)
| c-myc internal ribosome entry site (IRES) | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of IRES_c-myc | |
| Identifiers | |
| Symbol | IRES_c-myc |
| Alt. Symbols | c-myc_IRES |
| Rfam | RF00216 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | 0043022 |
| SO | 0000243 |
The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent translation pathway.[1]
References
- ↑ Le Quesne, JP; Stoneley M; Fraser GA; Willis AE (2001). "Derivation of a structural model for the c-myc IRES". J Mol Biol 310 (1): 111–126. doi:10.1006/jmbi.2001.4745. PMID 11419940.
External links
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