PDGFB

Platelet-derived growth factor beta polypeptide
PDB rendering based on 1pdg.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1PDG​, 3MJG​, 4HQU​, 4HQX​, 4QCI​
Identifiers
Symbols	PDGFB ; IBGC5; PDGF-2; PDGF2; SIS; SSV; c-sis
External IDs	OMIM: 190040 MGI: 97528 HomoloGene: 74303 GeneCards: PDGFB Gene
Gene ontology Molecular function • platelet-derived growth factor receptor binding • protein binding • collagen binding • growth factor activity • superoxide-generating NADPH oxidase activator activity • chemoattractant activity • identical protein binding • protein homodimerization activity • protein heterodimerization activity • platelet-derived growth factor binding Cellular component • Golgi membrane • extracellular region • extracellular space • cytoplasm • endoplasmic reticulum lumen • cell surface • basolateral plasma membrane • platelet alpha granule lumen Biological process • response to hypoxia • embryonic placenta development • positive regulation of endothelial cell proliferation • monocyte chemotaxis • platelet degranulation • positive regulation of glomerular filtration • DNA replication • protein phosphorylation • epidermal growth factor receptor signaling pathway • transforming growth factor beta receptor signaling pathway • heart development • blood coagulation • positive regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • response to wounding • negative regulation of phosphatidylinositol biosynthetic process • negative regulation of platelet activation • positive regulation of gene expression • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of smooth muscle cell migration • cell growth • peptidyl-serine phosphorylation • peptidyl-tyrosine phosphorylation • hemopoiesis • platelet activation • extracellular matrix organization • positive regulation of cell migration • positive regulation of protein autophosphorylation • negative regulation of protein binding • activation of protein kinase activity • activation of protein kinase B activity • response to estradiol • response to insulin • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • paracrine signaling • Fc-epsilon receptor signaling pathway • response to drug • positive regulation of MAP kinase activity • positive regulation of MAPK cascade • positive regulation of blood vessel endothelial cell migration • positive regulation of phosphatidylinositol 3-kinase activity • innate immune response • positive regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of DNA replication • positive regulation of mitotic nuclear division • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • platelet-derived growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of fibroblast proliferation • positive regulation of smooth muscle cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • positive chemotaxis • positive regulation of chemotaxis • cell chemotaxis • positive regulation of protein tyrosine kinase activity • positive regulation of ERK1 and ERK2 cascade • protein kinase C signaling • cellular response to growth factor stimulus • cellular response to mycophenolic acid • positive regulation of glomerular mesangial cell proliferation • metanephric glomerular mesangial cell development • reactive oxygen species metabolic process • positive regulation of calcium ion import • positive regulation of hyaluronan biosynthetic process • positive regulation of reactive oxygen species metabolic process • positive regulation of DNA biosynthetic process • positive regulation of metanephric mesenchymal cell migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5155	18591
Ensembl	ENSG00000100311	ENSMUSG00000000489
UniProt	P01127	P31240
RefSeq (mRNA)	NM_002608	NM_011057
RefSeq (protein)	NP_002599	NP_035187
Location (UCSC)	Chr 22: 39.22 – 39.24 Mb	Chr 15: 80 – 80.01 Mb
PubMed search

Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene.^[1][2]

Function

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha (PDGFA) polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds.

Clinical significance

Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.^[3]

See also

• Platelet-derived growth factor

References

1. Ratner L, Josephs SF, Jarrett R, Reitz MS, Wong-Staal F (Sep 1985). "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor". Nucleic Acids Res 13 (14): 5007–18. doi:10.1093/nar/13.14.5007. PMC 321845. PMID 2991848.
2. Clements JM, Bawden LJ, Bloxidge RE, Catlin G, Cook AL, Craig S, Drummond AH, Edwards RM, Fallon A, Green DR (Jan 1992). "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation". EMBO J 10 (13): 4113–20. PMC 453161. PMID 1661670.
3. "Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)".

Further reading

• Kurup S, Abramsson A, Li JP, Lindahl U, Kjellen L, Betsholtz C, Gerhardt H, Spillmann D (2006). "Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment". Biochem. Soc. Trans. 34 (Pt 3): 454–5. doi:10.1042/BST0340454. PMID 16709185.