CBX2 (gene)

Chromobox homolog 2
PDB rendering based on 2d9u.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2D9U​, 3H91​
Identifiers
Symbols	CBX2 ; CDCA6; M33; SRXY5
External IDs	OMIM: 602770 MGI: 88289 HomoloGene: 7256 GeneCards: CBX2 Gene
Gene ontology Molecular function • DNA binding • chromatin binding • protein binding • methylated histone binding Cellular component • euchromatin • heterochromatin • nucleus • nucleoplasm • PcG protein complex • PRC1 complex Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • chromatin modification • protein sumoylation • cell differentiation • post-translational protein modification • cellular protein metabolic process • development of primary sexual characteristics Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84733	12416
Ensembl	ENSG00000173894	ENSMUSG00000025577
UniProt	Q14781	P30658
RefSeq (mRNA)	NM_005189	NM_007623
RefSeq (protein)	NP_005180	NP_031649
Location (UCSC)	Chr 17: 79.78 – 79.79 Mb	Chr 11: 119.02 – 119.03 Mb
PubMed search

Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene.^[1][2][3] According to a New Scientist article CBX2 controls human sex even more so than X/Y chromosomes.^[4]

Interactions

CBX2 (gene) has been shown to interact with RYBP.^[5] It also interacts with the testis determining factor encoded by the SRY gene on the Y chromosome, as both proteins are necessary components of the male cascade.

References

1. Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJ, Fontes M (Jul 1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics 26 (1): 130–3. doi:10.1016/0888-7543(95)80091-Y. PMID 7782071.
2. Chodak GW (Nov 1989). "Early detection and screening for prostatic cancer". Urology 34 (4 Suppl): 10–2; discussion 46–56. doi:10.1016/0090-4295(89)90228-8. PMID 2477932.
3. "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)".
4. Ewen Callaway. "Girl with Y chromosome sheds light on maleness ", New Scientist, 2009-04-09. Retrieved on 2009-04-14.
5. García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
• Katoh-Fukui Y, Tsuchiya R, Shiroishi T, Nakahara Y, Hashimoto N, Noguchi K, Higashinakagawa T (1998). "Male-to-female sex reversal in M33 mutant mice". Nature 393 (6686): 688–92. doi:10.1038/31482. PMID 9641679.
• Pearce JJ, Singh PB, Gaunt SJ (1992). "The mouse has a Polycomb-like chromobox gene". Development 114 (4): 921–9. PMID 1352241.