RYBP

RING1 and YY1 binding protein
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3IXS​
Identifiers
Symbols	RYBP ; AAP1; DEDAF; YEAF1
External IDs	OMIM: 607535 MGI: 1929059 HomoloGene: 8159 GeneCards: RYBP Gene
Gene ontology Molecular function • DNA binding • transcription corepressor activity • protein binding • zinc ion binding Cellular component • nucleoplasm • cytoplasm • PcG protein complex Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • apoptotic process • multicellular organismal development • histone H2A monoubiquitination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23429	56353
Ensembl	ENSG00000163602	ENSMUSG00000072872
UniProt	Q8N488	Q8CCI5
RefSeq (mRNA)	NM_012234	NM_019743
RefSeq (protein)	NP_036366	NP_062717
Location (UCSC)	Chr 3: 72.37 – 72.45 Mb	Chr 6: 100.23 – 100.29 Mb
PubMed search

RING1 and YY1-binding protein is a protein that in humans is encoded by the RYBP gene.^[1][2]

Interactions

RYBP has been shown to interact with:

• Abl gene,^[3]
• CBX2,^[1]
• Caspase 10,^[4]
• E2F2,^[5]
• E2F3,^[5]
• Mdm2,^[6]
• RING1,^[1][7] and
• YY1.^[1]

References

1. García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
2. "Entrez Gene: RYBP RING1 and YY1 binding protein".
3. Zhu J, Shore SK (Dec 1996). "c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein". Molecular and Cellular Biology 16 (12): 7054–62. doi:10.1128/mcb.16.12.7054. PMC 231708. PMID 8943360.
4. Zheng L, Schickling O, Peter ME, Lenardo MJ (Aug 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". The Journal of Biological Chemistry 276 (34): 31945–52. doi:10.1074/jbc.M102799200. PMID 11395500.
5. Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
6. Chen D, Zhang J, Li M, Rayburn ER, Wang H, Zhang R (Feb 2009). "RYBP stabilizes p53 by modulating MDM2". EMBO Reports 10 (2): 166–72. doi:10.1038/embor.2008.231. PMC 2637313. PMID 19098711.
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Zhu J, Shore SK (Dec 1996). "c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein". Molecular and Cellular Biology 16 (12): 7054–62. doi:10.1128/mcb.16.12.7054. PMC 231708. PMID 8943360.
• Trimarchi JM, Fairchild B, Wen J, Lees JA (Feb 2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex". Proceedings of the National Academy of Sciences of the United States of America 98 (4): 1519–24. doi:10.1073/pnas.041597698. PMC 29289. PMID 11171983.
• Zheng L, Schickling O, Peter ME, Lenardo MJ (Aug 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". The Journal of Biological Chemistry 276 (34): 31945–52. doi:10.1074/jbc.M102799200. PMID 11395500.
• Sawa C, Yoshikawa T, Matsuda-Suzuki F, Deléhouzée S, Goto M, Watanabe H, Sawada J, Kataoka K, Handa H (Jun 2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors". The Journal of Biological Chemistry 277 (25): 22484–90. doi:10.1074/jbc.M203060200. PMID 11953439.
• Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
• Guelen L, Paterson H, Gäken J, Meyers M, Farzaneh F, Tavassoli M (Feb 2004). "TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells". Oncogene 23 (5): 1153–65. doi:10.1038/sj.onc.1207224. PMID 14691460.
• Danen-van Oorschot AA, Voskamp P, Seelen MC, van Miltenburg MH, Bolk MW, Tait SW, Boesen-de Cock JG, Rohn JL, Borst J, Noteborn MH (May 2004). "Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing". Cell Death and Differentiation 11 (5): 564–73. doi:10.1038/sj.cdd.4401391. PMID 14765135.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.