CCHCR1

Coiled-coil alpha-helical rod protein 1
Identifiers
Symbols CCHCR1 ; C6orf18; HCR; SBP
External IDs OMIM: 605310 MGI: 2385321 HomoloGene: 10396 GeneCards: CCHCR1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 54535 240084
Ensembl ENSG00000204536 ENSMUSG00000040312
UniProt Q8TD31 Q8K2I2
RefSeq (mRNA) NM_001105563 NM_146248
RefSeq (protein) NP_001099033 NP_666360
Location (UCSC) Chr 6:
31.14 – 31.16 Mb		 Chr 17:
35.52 – 35.53 Mb
PubMed search

Coiled-coil alpha-helical rod protein 1, also known as CCHCR1, is a protein which in humans is encoded by the CCHCR1 gene.[1][2][3]

Gene

The Human CCHCR1 gene is located at 6p21.33. It is also known as Coiled-Coil Alphahelical Rod Protein 1, C6orf18, Putative Gene 8 Protein, SBP, HCR (A-Helix Coiled-Coil Rod Homologue), pg8, StAR-Binding Protein, and Pg8.

Homology

Homologes for CCHCR1 are conserved through tetrapods.

Orthologs

CCHCR1 has orthologs throughout vertebrates.

Phylogeny

Phylogenetic analysis with ClustalW indicated that CCHCR1

The CCHCR1 gene has

Protein

Structure

The structure of CCHCR1 is primarily composed of alpha-helices, coils, and a small amount of beta sheets, according to PELE.[4]

Interacting Proteins

CCHCR1 has been shown to interact with POLR2C,[5] KRT17 ,[6] TOP3B,[7] Steroidogenic acute regulatory protein,[6] TRAF4,[8] HLA-C,[9] TCF19,[9] SNX29,[10] EEF1D,[11] and EEF1B2.[11]

Clinical significance

In genetically engineered mice, certain CCHCR1 polymorphisms cause upregulation of the expression of cytokeratins 6 (KRT6A), 16 (KRT16) and 17 (KRT17) and change in expression in other genes associated with terminal differentiation and formation of the cornified cell envelope. These CCHCR1 polymorphisms may therefore be associated with a susceptibility to psoriasis.[12] Defective functioning of CCHCR1 may lead to abnormal keratinocyte proliferation which is a key feature of psoriasis.[13]

CCHCR1 polymorphisms have also been found to be associated with multiple sclerosis.[14]

See also

References

  1. ↑ "Entrez Gene: CCHCR1 coiled-coil alpha-helical rod protein 1".
  2. ↑ Asumalahti K, Laitinen T, Itkonen-Vatjus R, Lokki ML, Suomela S, Snellman E, Saarialho-Kere U, Kere J (June 2000). "A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele". Hum. Mol. Genet. 9 (10): 1533–42. doi:10.1093/hmg/9.10.1533. PMID 10888604.
  3. ↑ Oka A, Tamiya G, Tomizawa M, Ota M, Katsuyama Y, Makino S, Shiina T, Yoshitome M, Iizuka M, Sasao Y, Iwashita K, Kawakubo Y, Sugai J, Ozawa A, Ohkido M, Kimura M, Bahram S, Inoko H (November 1999). "Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene". Hum. Mol. Genet. 8 (12): 2165–70. doi:10.1093/hmg/8.12.2165. PMID 10545595.
  4. ↑ Boudreau, A. E. (Mar 1999). "PELE—a version of the MELTS software program for the PC platform". Comput. Geosci. 25 (2): 201–203. doi:10.1016/S0098-3004(98)00117-4. ISSN 0098-3004.
  5. ↑ Corbi N, Bruno T, De Angelis R, Di Padova M, Libri V, Di Certo MG, Spinardi L, Floridi A, Fanciulli M, Passananti C (September 2005). "RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product". J. Cell. Sci. 118 (Pt 18): 4253–60. doi:10.1242/jcs.02545. PMID 16141233.
  6. 1 2 Tervaniemi MH, Siitonen HA, Söderhäll C, Minhas G, Vuola J, Tiala I, Sormunen R, Samuelsson L, Suomela S, Kere J, Elomaa O (2012). "Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization". PLOS ONE 7 (11): e49920. doi:10.1371/journal.pone.0049920. PMID 23189171.
  7. ↑ Nicholas TJ, Baker C, Eichler EE, Akey JM (16 August 2011). "A high-resolution integrated map of copy number polymorphisms within and between breeds of the modern domesticated dog". BMC Genomics 12: 414. doi:10.1186/1471-2164-12-414. PMID 21846351.
  8. ↑ Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS (Aug 2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". The Journal of Biological Chemistry 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963.
  9. 1 2 Petersdorf EW, Malkki M, Gooley TA, Spellman SR, Haagenson MD, Horowitz MM, Wang T (Jul 2012). "MHC-resident variation affects risks after unrelated donor hematopoietic cell transplantation". Science Translational Medicine 4 (144): 144ra101. doi:10.1126/scitranslmed.3003974. PMID 22837536.
  10. ↑ Yang HH, Hu N, Wang C, Ding T, Dunn BK, Goldstein AM, Taylor PR, Lee MP (23 February 2010). "Influence of genetic background and tissue types on global DNA methylation patterns". PLOS ONE 5 (2): e9355. doi:10.1371/journal.pone.0009355. PMID 20186319.
  11. 1 2 Corbi N, Batassa EM, Pisani C, Onori A, Di Certo MG, Strimpakos G, Fanciulli M, Mattei E, Passananti C (31 December 2010). "The eEF1γ subunit contacts RNA polymerase II and binds vimentin promoter region". PLOS ONE 5 (12): e14481. doi:10.1371/journal.pone.0014481. PMID 21217813.
  12. ↑ Elomaa O, Majuri I, Suomela S, Asumalahti K, Jiao H, Mirzaei Z, Rozell B, Dahlman-Wright K, Pispa J, Kere J, Saarialho-Kere U (August 2004). "Transgenic mouse models support HCR as an effector gene in the PSORS1 locus". Hum. Mol. Genet. 13 (15): 1551–61. doi:10.1093/hmg/ddh178. PMID 15190014.
  13. ↑ Tiala I, Wakkinen J, Suomela S, Puolakkainen P, Tammi R, Forsberg S, Rollman O, Kainu K, Rozell B, Kere J, Saarialho-Kere U, Elomaa O (April 2008). "The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in transgenic mice". Hum. Mol. Genet. 17 (7): 1043–51. doi:10.1093/hmg/ddm377. PMID 18174193.
  14. ↑ Lin X, Deng FY, Lu X, Lei SF (2015). "Susceptibility Genes for Multiple Sclerosis Identified in a Gene-Based Genome-Wide Association Study". Journal of Clinical Neurology (Seoul, Korea) 11 (4): 311–8. doi:10.3988/jcn.2015.11.4.311. PMC 4596110. PMID 26320842.

Further reading

  • Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098. 
  • Oka A, Tamiya G, Tomizawa M, Ota M, Katsuyama Y, Makino S, Shiina T, Yoshitome M, Iizuka M, Sasao Y, Iwashita K, Kawakubo Y, Sugai J, Ozawa A, Ohkido M, Kimura M, Bahram S, Inoko H (1999). "Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene". Hum. Mol. Genet. 8 (12): 2165–70. doi:10.1093/hmg/8.12.2165. PMID 10545595. 
  • Asumalahti K, Laitinen T, Itkonen-Vatjus R, Lokki ML, Suomela S, Snellman E, Saarialho-Kere U, Kere J (2000). "A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele". Hum. Mol. Genet. 9 (10): 1533–42. doi:10.1093/hmg/9.10.1533. PMID 10888604. 
  • O'Brien KP, Holm SJ, Nilsson S, Carlén L, Rosenmüller T, Enerbäck C, Inerot A, Ståhle-Bäckdahl M (2001). "The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene". J. Invest. Dermatol. 116 (5): 750–4. doi:10.1046/j.0022-202x.2001.01323.x. PMID 11348465. 
  • Asumalahti K, Veal C, Laitinen T, Suomela S, Allen M, Elomaa O, Moser M, de Cid R, Ripatti S, Vorechovsky I, Marcusson JA, Nakagawa H, Lazaro C, Estivill X, Capon F, Novelli G, Saarialho-Kere U, Barker J, Trembath R, Kere J (2002). "Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus". Hum. Mol. Genet. 11 (5): 589–97. doi:10.1093/hmg/11.5.589. PMID 11875053. 
  • Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". J. Biol. Chem. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963. 
  • Sugawara T, Shimizu H, Hoshi N, Nakajima A, Fujimoto S (2003). "Steroidogenic acute regulatory protein-binding protein cloned by a yeast two-hybrid system". J. Biol. Chem. 278 (43): 42487–94. doi:10.1074/jbc.M302291200. PMID 12909641. 
  • Suomela S, Elomaa O, Asumalahti K, Kariniemi AL, Karvonen SL, Peltonen J, Kere J, Saarialho-Kere U (2003). "HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes". J. Invest. Dermatol. 121 (6): 1360–4. doi:10.1046/j.1523-1747.2003.12642.x. PMID 14675183. 
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Chang J, Nicolas E, Marks D, Sander C, Lerro A, Buendia MA, Xu C, Mason WS, Moloshok T, Bort R, Zaret KS, Taylor JM (2004). "miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1". RNA Biol 1 (2): 106–13. doi:10.4161/rna.1.2.1066. PMID 17179747. 
  • Tiala I, Suomela S, Huuhtanen J, Wakkinen J, Hölttä-Vuori M, Kainu K, Ranta S, Turpeinen U, Hämäläinen E, Jiao H, Karvonen SL, Ikonen E, Kere J, Saarialho-Kere U, Elomaa O (2007). "The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes". J. Mol. Med. 85 (6): 589–601. doi:10.1007/s00109-006-0155-0. PMID 17221218. 
  • Suomela S, Kainu K, Onkamo P, Tiala I, Himberg J, Koskinen L, Snellman E, Karvonen SL, Karvonen J, Uurasmaa T, Reunala T, Kivikäs K, Jansén CT, Holopainen P, Elomaa O, Kere J, Saarialho-Kere U (2007). "Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis". Acta Derm. Venereol. 87 (2): 127–34. doi:10.2340/00015555-0184. PMID 17340018. 
  • Elomaa O, Majuri I, Suomela S, Asumalahti K, Jiao H, Mirzaei Z, Rozell B, Dahlman-Wright K, Pispa J, Kere J, Saarialho-Kere U (Aug 2004). "Transgenic mouse models support HCR as an effector gene in the PSORS1 locus". Human Molecular Genetics 13 (15): 1551–61. doi:10.1093/hmg/ddh178. PMID 15190014. 
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