CDC42EP3

CDC42 effector protein (Rho GTPase binding) 3
Identifiers
Symbols	CDC42EP3 ; BORG2; CEP3; UB1
External IDs	OMIM: 606133 MGI: 2384718 HomoloGene: 4708 GeneCards: CDC42EP3 Gene
Gene ontology Molecular function • GTPase activator activity • cytoskeletal regulatory protein binding • GTP-Rho binding Cellular component • cytoplasm • plasma membrane • endomembrane system • actin cytoskeleton Biological process • signal transduction • Rho protein signal transduction • regulation of cell shape • positive regulation of actin filament polymerization • positive regulation of pseudopodium assembly • positive regulation of GTPase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10602	260409
Ensembl	ENSG00000163171	ENSMUSG00000036533
UniProt	Q9UKI2	Q9CQC5
RefSeq (mRNA)	NM_001270436	NM_026514
RefSeq (protein)	NP_001257365	NP_080790
Location (UCSC)	Chr 2: 37.64 – 37.74 Mb	Chr 17: 79.33 – 79.36 Mb
PubMed search

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.^[1][2][3]

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.^[3]

Interactions

CDC42EP3 has been shown to interact with CDC42^[1][4] and RHOQ.^[4]

References

1. Alberts AS, Bouquin N, Johnston LH, Treisman R (May 1998). "Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7". J Biol Chem 273 (15): 8616–22. doi:10.1074/jbc.273.15.8616. PMID 9535835.
2. Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
3. "Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3".
4. Joberty, G; Perlungher R R; Macara I G (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. (UNITED STATES) 19 (10): 6585–97. ISSN 0270-7306. PMC 84628. PMID 10490598.

Further reading

• Joberty G, Perlungher RR, Macara IG (2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. PMC 84628. PMID 10490598.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Joberty G, Perlungher RR, Sheffield PJ; et al. (2001). "Borg proteins control septin organization and are negatively regulated by Cdc42". Nat. Cell Biol. 3 (10): 861–6. doi:10.1038/ncb1001-861. PMID 11584266.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.