RHOQ

Ras homolog family member Q
PDB rendering based on 2atx.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2ATX​
Identifiers
Symbols	RHOQ ; ARHQ; HEL-S-42; RASL7A; TC10; TC10A
External IDs	OMIM: 605857 MGI: 1931553 HomoloGene: 22704 GeneCards: RHOQ Gene
Gene ontology Molecular function • GTPase activity • profilin binding • GTP binding • GBD domain binding Cellular component • cytosol • actin filament • plasma membrane • Golgi-associated vesicle membrane • membrane raft • extracellular exosome Biological process • small GTPase mediated signal transduction • insulin receptor signaling pathway • regulation of cell shape • cortical actin cytoskeleton organization • cellular response to insulin stimulus • regulation of actin cytoskeleton organization • positive regulation of transcription from RNA polymerase II promoter • GTP metabolic process • positive regulation of glucose import • regulation of small GTPase mediated signal transduction • positive regulation of filopodium assembly • negative regulation of establishment of protein localization to plasma membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23433	104215
Ensembl	ENSG00000119729	ENSMUSG00000024143
UniProt	P17081	Q8R527
RefSeq (mRNA)	NM_012249	NM_145491
RefSeq (protein)	NP_036381	NP_663466
Location (UCSC)	Chr 2: 46.54 – 46.58 Mb	Chr 17: 86.96 – 87 Mb
PubMed search

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.^[1][2]

TC10 is a member of the RAS superfamily of small GTP-binding proteins (see HRAS, MIM 190020) involved in insulin-stimulated glucose uptake.[supplied by OMIM]^[2]

In melanocytic cells RHOQ gene expression may be regulated by MITF.^[3]

Interactions

RHOQ has been shown to interact with EXOC7,^[4] GOPC,^[5] PARD6B,^[5][6] WASL,^[7] CDC42EP2,^[8] TRIP10^[9] and CDC42EP3.^[8]

References

1. Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol 10 (4): 1793–8. PMC 362288. PMID 2108320.
2. "Entrez Gene: RHOQ ras homolog gene family, member Q".
3. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
4. Inoue, Mayumi; Chang Louise; Hwang Joseph; Chiang Shian-Huey; Saltiel Alan R (April 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin". Nature (England) 422 (6932): 629–33. doi:10.1038/nature01533. ISSN 0028-0836. PMID 12687004.
5. Neudauer, C L; Joberty G; Macara I G (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. (United States) 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. ISSN 0006-291X. PMID 11162552.
6. Joberty, G; Petersen C; Gao L; Macara I G (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. (ENGLAND) 2 (8): 531–9. doi:10.1038/35019573. ISSN 1465-7392. PMID 10934474.
7. Abe, Tomoyuki; Kato Masayoshi; Miki Hiroaki; Takenawa Tadaomi; Endo Takeshi (January 2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". J. Cell. Sci. (England) 116 (Pt 1): 155–68. doi:10.1242/jcs.00208. ISSN 0021-9533. PMID 12456725.
8. Joberty, G; Perlungher R R; Macara I G (October 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. (UNITED STATES) 19 (10): 6585–97. ISSN 0270-7306. PMC 84628. PMID 10490598.
9. Chang, Louise; Adams Rachael D; Saltiel Alan R (October 2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (20): 12835–40. doi:10.1073/pnas.202495599. ISSN 0027-8424. PMC 130546. PMID 12242347.

Further reading

• Murphy GA, Solski PA, Jillian SA, et al. (1999). "Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth". Oncogene 18 (26): 3831–45. doi:10.1038/sj.onc.1202758. PMID 10445846.
• Joberty G, Perlungher RR, Macara IG (2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. PMC 84628. PMID 10490598.
• Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474.
• Vignal E, De Toledo M, Comunale F, et al. (2000). "Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42". J. Biol. Chem. 275 (46): 36457–64. doi:10.1074/jbc.M003487200. PMID 10967094.
• Michaelson D, Silletti J, Murphy G, et al. (2001). "Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding". J. Cell Biol. 152 (1): 111–26. doi:10.1083/jcb.152.1.111. PMC 2193662. PMID 11149925.
• Neudauer CL, Joberty G, Macara IG (2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
• Chiang SH, Hou JC, Hwang J, et al. (2002). "Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport". J. Biol. Chem. 277 (15): 13067–73. doi:10.1074/jbc.M109471200. PMID 11821390.
• Kanzaki M, Watson RT, Hou JC, et al. (2003). "Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes". Mol. Biol. Cell 13 (7): 2334–46. doi:10.1091/mbc.01-10-0490. PMC 117317. PMID 12134073.
• Chang L, Adams RD, Saltiel AR (2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12835–40. doi:10.1073/pnas.202495599. PMC 130546. PMID 12242347.
• Abe T, Kato M, Miki H, et al. (2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". J. Cell. Sci. 116 (Pt 1): 155–68. doi:10.1242/jcs.00208. PMID 12456725.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
• Watson RT, Furukawa M, Chiang SH, et al. (2003). "The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes". Mol. Cell. Biol. 23 (3): 961–74. doi:10.1128/MCB.23.3.961-974.2003. PMC 140699. PMID 12529401.
• Inoue M, Chang L, Hwang J, et al. (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin". Nature 422 (6932): 629–33. doi:10.1038/nature01533. PMID 12687004.
• Chunqiu Hou J, Pessin JE (2004). "Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin". Mol. Biol. Cell 14 (9): 3578–91. doi:10.1091/mbc.E03-01-0012. PMC 196551. PMID 12972548.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ng Y, Tan I, Lim L, Leung T (2004). "Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding". J. Biol. Chem. 279 (33): 34156–64. doi:10.1074/jbc.M405252200. PMID 15194684.
• Ruusala A, Aspenström P (2004). "Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology". FEBS Lett. 572 (1–3): 159–66. doi:10.1016/j.febslet.2004.06.095. PMID 15304341.
• Nalbant P, Hodgson L, Kraynov V, et al. (2004). "Activation of endogenous Cdc42 visualized in living cells". Science 305 (5690): 1615–9. doi:10.1126/science.1100367. PMID 15361624.