PARD6B

Par-6 family cell polarity regulator beta
PDB rendering based on 1nf3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1nf3​
Identifiers
Symbols	PARD6B ; PAR6B
External IDs	OMIM: 608975 MGI: 2135605 HomoloGene: 23302 GeneCards: PARD6B Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • cytoplasm • cytosol • plasma membrane • bicellular tight junction • cell cortex • protein complex • apical part of cell • extracellular exosome Biological process • protein complex assembly • cell-cell junction assembly • cell cycle • establishment or maintenance of cell polarity • axonogenesis • regulation of cell migration • cell junction assembly • cell-cell junction organization • cell division • bicellular tight junction assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84612	58220
Ensembl	ENSG00000124171	ENSMUSG00000044641
UniProt	Q9BYG5	Q9JK83
RefSeq (mRNA)	NM_032521	NM_021409
RefSeq (protein)	NP_115910	NP_067384
Location (UCSC)	Chr 20: 50.73 – 50.76 Mb	Chr 2: 168.08 – 168.1 Mb
PubMed search

Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.^[1][2]

Function

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.^[2]

Interactions

PARD6B has been shown to interact with:

• CDC42,^[1][3][4]
• Protein kinase Mζ,^[1]
• RAC1,^[1] and
• RHOQ.^[3][4]

References

1. Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256.
2. "Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans)".
3. Neudauer CL, Joberty G, Macara IG (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
4. Joberty G, Petersen C, Gao L, Macara IG (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474.

Further reading

• Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474.
• Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.
• Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
• Hurd TW, Gao L, Roh MH, Macara IG, Margolis B (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177.
• Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S (2004). "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity". Curr. Biol. 13 (9): 734–43. doi:10.1016/S0960-9822(03)00244-6. PMID 12725730.
• Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
• Labhart P, Karmakar S, Salicru EM, Egan BS, Alexiadis V, O'Malley BW, Smith CL (2005). "Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1339–44. doi:10.1073/pnas.0409578102. PMC 547886. PMID 15677324.