TRIP10

Thyroid hormone receptor interactor 10
PDB rendering based on 2ct4.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CT4​, 2EFK​, 2KE4​
Identifiers
Symbols	TRIP10 ; CIP4; HSTP; STOT; STP; TRIP-10
External IDs	OMIM: 604504 MGI: 2146901 HomoloGene: 99728 GeneCards: TRIP10 Gene
Gene ontology Molecular function • protein binding • lipid binding • identical protein binding Cellular component • phagocytic cup • nucleoplasm • cytoplasm • lysosome • Golgi apparatus • cytosol • cytoskeleton • cell cortex • cell projection • intracellular membrane-bounded organelle • perinuclear region of cytoplasm • extracellular exosome Biological process • endocytosis • cell communication • signal transduction • small GTPase mediated signal transduction • actin cytoskeleton organization • regulation of small GTPase mediated signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9322	106628
Ensembl	ENSG00000125733	ENSMUSG00000019487
UniProt	Q15642	Q8CJ53
RefSeq (mRNA)	NM_001288962	NM_001242389
RefSeq (protein)	NP_001275891	NP_001229318
Location (UCSC)	Chr 19: 6.74 – 6.75 Mb	Chr 17: 57.25 – 57.26 Mb
PubMed search

Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene.^[1][2][3][4]

Interactions

TRIP10 has been shown to interact with STAT3,^[5] Wiskott-Aldrich syndrome protein,^[6] Huntingtin,^[7] CDC42,^[2][6] AKAP9^[8] and RHOQ.^[9]

References

1. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
2. Aspenstrom P (August 1997). "A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton". Curr Biol 7 (7): 479–87. doi:10.1016/S0960-9822(06)00219-3. PMID 9210375.
3. Tsuji E, Tsuji Y (April 2001). "Molecular cloning and chromosomal localization of human salt-tolerant protein". Genetica 108 (3): 259–62. doi:10.1023/A:1004132919896. PMID 11294612.
4. "Entrez Gene: TRIP10 thyroid hormone receptor interactor 10".
5. Chung, Young-Hwa; Cho Nam-hyuk; Garcia Maria Ines; Lee Sun-Hwa; Feng Pinghui; Jung Jae U (June 2004). "Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein". J. Virol. (United States) 78 (12): 6489–97. doi:10.1128/JVI.78.12.6489-6497.2004. ISSN 0022-538X. PMC 416526. PMID 15163742.
6. Tian, L; Nelson D L; Stewart D M (March 2000). "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules". J. Biol. Chem. (UNITED STATES) 275 (11): 7854–61. doi:10.1074/jbc.275.11.7854. ISSN 0021-9258. PMID 10713100.
7. Holbert, Sébastien; Dedeoglu Alpaslan; Humbert Sandrine; Saudou Frédéric; Ferrante Robert J; Néri Christian (March 2003). "Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (5): 2712–7. doi:10.1073/pnas.0437967100. ISSN 0027-8424. PMC 151406. PMID 12604778.
8. Larocca, M Cecilia; Shanks Ryan A; Tian Lan; Nelson David L; Stewart Donn M; Goldenring James R (June 2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell (United States) 15 (6): 2771–81. doi:10.1091/mbc.E03-10-0757. ISSN 1059-1524. PMC 420101. PMID 15047863.
9. Chang, Louise; Adams Rachael D; Saltiel Alan R (October 2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (20): 12835–40. doi:10.1073/pnas.202495599. ISSN 0027-8424. PMC 130546. PMID 12242347.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Tian L, Nelson DL, Stewart DM (2000). "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules.". J. Biol. Chem. 275 (11): 7854–61. doi:10.1074/jbc.275.11.7854. PMID 10713100.
• Linder S, Hüfner K, Wintergerst U, Aepfelbacher M (2001). "Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages.". J. Cell. Sci. 113 Pt 23: 4165–76. PMID 11069762.
• Richnau N, Aspenström P (2001). "Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1.". J. Biol. Chem. 276 (37): 35060–70. doi:10.1074/jbc.M103540200. PMID 11431473.
• Yuan R, Fan S, Achary M, et al. (2001). "Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage.". Cancer Res. 61 (21): 8022–31. PMID 11691828.
• Wang L, Rudert WA, Grishin A, et al. (2002). "Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms.". Biochem. Biophys. Res. Commun. 293 (5): 1426–30. doi:10.1016/S0006-291X(02)00398-4. PMID 12054674.
• Chang L, Adams RD, Saltiel AR (2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12835–40. doi:10.1073/pnas.202495599. PMC 130546. PMID 12242347.
• Dombrosky-Ferlan P, Grishin A, Botelho RJ, et al. (2003). "Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup.". Blood 101 (7): 2804–9. doi:10.1182/blood-2002-03-0851. PMID 12456510.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Holbert S, Dedeoglu A, Humbert S, et al. (2003). "Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2712–7. doi:10.1073/pnas.0437967100. PMC 151406. PMID 12604778.
• Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
• Morin F, Vannier B, Houdart F, et al. (2003). "A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins.". Mol. Vis. 9: 449–59. PMID 14502124.
• Larocca MC, Shanks RA, Tian L, et al. (2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus.". Mol. Biol. Cell 15 (6): 2771–81. doi:10.1091/mbc.E03-10-0757. PMC 420101. PMID 15047863.
• Chung YH, Cho NH, Garcia MI, et al. (2004). "Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein.". J. Virol. 78 (12): 6489–97. doi:10.1128/JVI.78.12.6489-6497.2004. PMC 416526. PMID 15163742.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yin X, Warner DR, Roberts EA, et al. (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue.". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID 15752756.