CLC (gene)

Charcot-Leyden crystal galectin
PDB rendering based on 1g86.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1G86​, 1HDK​, 1LCL​, 1QKQ​
Identifiers
Symbols	CLC ; GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN
External IDs	OMIM: 153310 HomoloGene: 130498 GeneCards: CLC Gene
EC number	3.1.1.5
Gene ontology Molecular function • lysophospholipase activity • protein binding • carbohydrate binding • cysteine-type endopeptidase activity involved in apoptotic process Cellular component • cytosol Biological process • regulation of T cell anergy • regulation of T cell cytokine production • multicellular organismal development • regulation of activated T cell proliferation • T cell apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1178	n/a
Ensembl	ENSG00000105205	n/a
UniProt	Q05315	n/a
RefSeq (mRNA)	NM_001828	n/a
RefSeq (protein)	NP_001819	n/a
Location (UCSC)	Chr 19: 39.73 – 39.74 Mb	n/a
PubMed search		n/a

Eosinophil lysophospholipase is an enzyme that in humans is encoded by the CLC gene.^[1][2]

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.^[2]

See also

• Charcot-Leyden crystals

References

1. Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.
2. "Entrez Gene: CLC Charcot-Leyden crystal protein".

Further reading

• Gleich GJ, Loegering DA, Mann KG, Maldonado JE (1976). "Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils". J. Clin. Invest. 57 (3): 633–40. doi:10.1172/JCI108319. PMC 436696. PMID 942977.
• Golightly LM, Thomas LL, Dvorak AM, Ackerman SJ (1992). "Charcot-Leyden crystal protein in the degranulation and recovery of activated basophils". J. Leukoc. Biol. 51 (4): 386–92. PMID 1373430.
• Dvorak AM, Weller PF, Monahan-Earley RA, et al. (1990). "Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) and peroxidase in macrophages, eosinophils, and extracellular matrix of the skin in the hypereosinophilic syndrome". Lab. Invest. 62 (5): 590–607. PMID 2160562.
• Dvorak AM, Letourneau L, Weller PF, Ackerman SJ (1990). "Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) to intracytoplasmic crystals in tumor cells of primary solid and papillary epithelial neoplasm of the pancreas". Lab. Invest. 62 (5): 608–15. PMID 2160563.
• Dvorak AM, Ackerman SJ (1989). "Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to granules and intragranular crystals in mature human basophils". Lab. Invest. 60 (4): 557–67. doi:10.1111/1523-1747.ep12703656. PMID 2709814.
• Sieker LC, Turley S, Le Trong I, et al. (1989). "Crystallographic characterization of human eosinophil Charcot-Leyden crystals". J. Mol. Biol. 204 (2): 489–91. doi:10.1016/0022-2836(88)90590-6. PMID 3221396.
• Weller PF, Bach D, Austen KF (1982). "Human eosinophil lysophospholipase: the sole protein component of Charcot-Leyden crystals". J. Immunol. 128 (3): 1346–9. PMID 6173432.
• Weller PF, Bach DS, Austen KF (1985). "Biochemical characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase)". J. Biol. Chem. 259 (24): 15100–5. PMID 6511787.
• Gomolin HI, Yamaguchi Y, Paulpillai AV, et al. (1993). "Human eosinophil Charcot-Leyden crystal protein: cloning and characterization of a lysophospholipase gene promoter". Blood 82 (6): 1868–74. PMID 8400237.
• Ackerman SJ, Corrette SE, Rosenberg HF, et al. (1993). "Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily". J. Immunol. 150 (2): 456–68. PMID 8419478.
• Leonidas DD, Elbert BL, Zhou Z, et al. (1996). "Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins". Structure 3 (12): 1379–93. doi:10.1016/S0969-2126(01)00275-1. PMID 8747464.
• Dyer KD, Handen JS, Rosenberg HF (1997). "The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes". Genomics 40 (2): 217–21. doi:10.1006/geno.1996.4590. PMID 9119387.
• Swaminathan GJ, Leonidas DD, Savage MP, et al. (1999). "Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution". Biochemistry 38 (42): 13837–43. doi:10.1021/bi990756e. PMID 10529229.
• Larramendy ML, Niini T, Elonen E, et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica 87 (6): 569–77. PMID 12031912.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Abedin MJ, Kashio Y, Seki M, et al. (2003). "Potential roles of galectins in myeloid differentiation into three different lineages". J. Leukoc. Biol. 73 (5): 650–6. doi:10.1189/jlb.0402163. PMID 12714580.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nielsen K, Heegaard S, Vorum H, et al. (2005). "Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients". Cornea 24 (6): 661–8. doi:10.1097/01.ico.0000153556.59407.69. PMID 16015083.