CNOT4

CCR4-NOT transcription complex, subunit 4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E4U, 1UR6
Identifiers
Aliases	CNOT4, CLONE243, NOT4, NOT4H
External IDs	MGI: 1859026 HomoloGene: 40870 GeneCards: 4850
Gene ontology Molecular function • ligase activity • ubiquitin-protein transferase activity • nucleotide binding • protein binding • nucleic acid binding • poly(A) RNA binding • metal ion binding • zinc ion binding • RNA binding Cellular component • cytosol • cytoplasm • CCR4-NOT complex • cell nucleus Biological process • protein ubiquitination • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • nuclear-transcribed mRNA poly(A) tail shortening • gene expression • protein autoubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4850	53621
Ensembl	ENSG00000080802	ENSMUSG00000038784
UniProt	O95628	Q8BT14
RefSeq (mRNA)	XM_011516252 NM_001008225 NM_001190847 NM_001190848 NM_001190849 NM_001190850 NM_013316	NM_001164411 NM_001164412 NM_001164413 NM_001164414 NM_016877 XM_011241407 XM_011241408
RefSeq (protein)	NP_001008226.1 NP_001177776.1 NP_001177777.1 NP_001177778.1 NP_001177779.1 NP_037448.2 XP_011514554.1	NP_001157883.1 NP_001157885.1 NP_058573.3 XP_011239709.1 XP_011239710.1
Location (UCSC)	Chr 7: 135.36 – 135.51 Mb	Chr 6: 35.02 – 35.13 Mb
PubMed search
Wikidata

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CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.^[1]

Function

The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010].

References

1. "Entrez Gene: CCR4-NOT transcription complex, subunit 4".

Further reading

• Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M (March 2012). "Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells". FASEB Journal 26 (3): 1239–50. doi:10.1096/fj.11-195875. PMID 22159038.
• Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT (March 2004). "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair". Journal of Molecular Biology 337 (1): 157–65. doi:10.1016/j.jmb.2004.01.031. PMID 15001359.
• Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT (September 2009). "Human Ccr4-Not complexes contain variable deadenylase subunits". The Biochemical Journal 422 (3): 443–53. doi:10.1042/BJ20090500. PMID 19558367.
• Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT (February 2002). "Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex". The EMBO Journal 21 (3): 355–64. doi:10.1093/emboj/21.3.355. PMC 125831. PMID 11823428.
• Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R (April 2004). "Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches". Structure 12 (4): 633–44. doi:10.1016/j.str.2004.03.004. PMID 15062086.
• Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (June 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision 8: 205–20. PMID 12107410.
• Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD (April 2009). "Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression". Genes & Development 23 (8): 951–62. doi:10.1101/gad.1769209. PMC 2675863. PMID 19346402.
• Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R (March 2001). "The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers". The Journal of Biological Chemistry 276 (13): 10185–90. doi:10.1074/jbc.M009298200. PMID 11087754.
• Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Research 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.