CSNK2A2

Casein kinase 2, alpha prime polypeptide
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3E3B​, 3OFM​, 3U87​
Identifiers
Symbols	CSNK2A2 ; CK2A2; CSNK2A1
External IDs	OMIM: 115442 MGI: 88547 HomoloGene: 20444 ChEMBL: 4070 GeneCards: CSNK2A2 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • protein binding • ATP binding • protein N-terminus binding Cellular component • nucleus • cytosol • PcG protein complex Biological process • mitotic cell cycle • transcription, DNA-templated • regulation of transcription, DNA-templated • protein phosphorylation • apoptotic process • axon guidance • Wnt signaling pathway • mitotic spindle checkpoint • regulation of mitophagy • positive regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1459	13000
Ensembl	ENSG00000070770	ENSMUSG00000046707
UniProt	P19784	O54833
RefSeq (mRNA)	NM_001896	NM_009974
RefSeq (protein)	NP_001887	NP_034104
Location (UCSC)	Chr 16: 58.16 – 58.2 Mb	Chr 8: 95.45 – 95.49 Mb
PubMed search

Casein kinase II subunit alpha' is an enzyme that in humans is encoded by the CSNK2A2 gene.^[1][2]

Interactions

CSNK2A2 has been shown to interact with over 160 different substrates.^[3]

CSNK2A2 has been shown to interact with:

• Activating transcription factor 2,^[4]
• ATF1,^[4]
• C-Fos,^[4]
• CREB binding protein,^[4]
• CSNK2B,^[5][6][7]
• FGF1,^[8]
• Nucleolin,^[9]
• PIN1,^[10]
• PTEN,^[8][11] and
• RELA.^[12]

References

1. Lozeman FJ, Litchfield DW, Piening C, Takio K, Walsh KA, Krebs EG (Jan 1991). "Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II". Biochemistry 29 (36): 8436–47. doi:10.1021/bi00488a034. PMID 2174700.
2. Yang-Feng TL, Zheng K, Kopatz I, Naiman T, Canaani D (Feb 1992). "Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit". Nucleic Acids Res 19 (25): 7125–9. doi:10.1093/nar/19.25.7125. PMC 332535. PMID 1766873.
3. Faust M, Montenarh M (September 2000). "Subcellular localization of protein kinase CK2. A key to its function?". Cell Tissue Res. 301 (3): 329–40. doi:10.1007/s004410000256. PMID 10994779.
4. Yamaguchi Y, Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H (August 1998). "Casein kinase II interacts with the bZIP domains of several transcription factors". Nucleic Acids Res. 26 (16): 3854–61. doi:10.1093/nar/26.16.3854. PMC 147779. PMID 9685505.
5. Kim MS, Lee YT, Kim JM, Cha JY, Bae YS (February 1998). "Characterization of protein interaction among subunits of protein kinase CKII in vivo and in vitro". Mol. Cells 8 (1): 43–8. PMID 9571630.
6. Marin O, Meggio F, Sarno S, Pinna LA (June 1997). "Physical dissection of the structural elements responsible for regulatory properties and intersubunit interactions of protein kinase CK2 beta-subunit". Biochemistry 36 (23): 7192–8. doi:10.1021/bi962885q. PMID 9188720.
7. Bosc DG, Graham KC, Saulnier RB, Zhang C, Prober D, Gietz RD, Litchfield DW (May 2000). "Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2". J. Biol. Chem. 275 (19): 14295–306. doi:10.1074/jbc.275.19.14295. PMID 10799509.
8. Skjerpen, Camilla Skiple; Nilsen Trine; Wesche Jørgen; Olsnes Sjur (Aug 2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity". EMBO J. (England) 21 (15): 4058–69. doi:10.1093/emboj/cdf402. ISSN 0261-4189. PMC 126148. PMID 12145206.
9. Li D, Dobrowolska G, Krebs EG (June 1996). "The physical association of casein kinase 2 with nucleolin". J. Biol. Chem. 271 (26): 15662–8. doi:10.1074/jbc.271.26.15662. PMID 8663258.
10. Messenger MM, Saulnier RB, Gilchrist AD, Diamond P, Gorbsky GJ, Litchfield DW (June 2002). "Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions". J. Biol. Chem. 277 (25): 23054–64. doi:10.1074/jbc.M200111200. PMID 11940573.
11. Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG (September 2002). "Direct identification of PTEN phosphorylation sites". FEBS Lett. 528 (1-3): 145–53. doi:10.1016/S0014-5793(02)03274-X. PMID 12297295.
12. Wang D, Westerheide SD, Hanson JL, Baldwin AS (October 2000). "Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II". J. Biol. Chem. 275 (42): 32592–7. doi:10.1074/jbc.M001358200. PMID 10938077.

Further reading

• Allende JE, Allende CC (1995). "Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation". FASEB J. 9 (5): 313–23. PMID 7896000.
• Faust M, Montenarh M (2001). "Subcellular localization of protein kinase CK2. A key to its function?". Cell Tissue Res. 301 (3): 329–40. doi:10.1007/s004410000256. PMID 10994779.