Carbonic anhydrase 4

Carbonic anhydrase IV
PDB rendering based on 1znc.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZNC​, 3F7B​, 3F7U​, 3FW3​
Identifiers
Symbols	CA4 ; CAIV; Car4; RP17
External IDs	OMIM: 114760 MGI: 1096574 HomoloGene: 20183 ChEMBL: 3729 GeneCards: CA4 Gene
EC number	4.2.1.1
Gene ontology Molecular function • carbonate dehydratase activity • protein binding • zinc ion binding Cellular component • rough endoplasmic reticulum • endoplasmic reticulum-Golgi intermediate compartment • Golgi apparatus • trans-Golgi network • plasma membrane • cell surface • membrane • basolateral plasma membrane • apical plasma membrane • sarcoplasmic reticulum • transport vesicle membrane • secretory granule membrane • anchored component of external side of plasma membrane • brush border membrane • sarcolemma • perinuclear region of cytoplasm • extracellular exosome Biological process • one-carbon metabolic process • bicarbonate transport • response to drug • small molecule metabolic process • organ development • response to steroid hormone Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	762	12351
Ensembl	ENSG00000167434	ENSMUSG00000000805
UniProt	P22748	Q64444
RefSeq (mRNA)	NM_000717	NM_007607
RefSeq (protein)	NP_000708	NP_031633
Location (UCSC)	Chr 17: 60.15 – 60.17 Mb	Chr 11: 84.96 – 84.97 Mb
PubMed search

Carbonic anhydrase 4 is an enzyme that in humans is encoded by the CA4 gene.^[1][2]

Function

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IV is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and of proximal renal tubules. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport.^[2]

Interactions

CA4 has been shown to interact with Band 3.^[3]

References

1. Okuyama T, Batanian JR, Sly WS (Aug 1993). "Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q". Genomics 16 (3): 678–84. doi:10.1006/geno.1993.1247. PMID 8325641.
2. "Entrez Gene: CA4 carbonic anhydrase IV".
3. Sterling D, Alvarez BV, Casey JR (Jul 2002). "The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV". J. Biol. Chem. 277 (28): 25239–46. doi:10.1074/jbc.M202562200. PMID 11994299.

Further reading

• Okuyama T, Sato S, Zhu XL, Waheed A, Sly WS (1992). "Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1315–9. doi:10.1073/pnas.89.4.1315. PMC 48440. PMID 1311094.
• Hageman GS, Zhu XL, Waheed A, Sly WS (1991). "Localization of carbonic anhydrase IV in a specific capillary bed of the human eye.". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2716–20. doi:10.1073/pnas.88.7.2716. PMC 51309. PMID 1901414.
• Zhu XL, Sly WS (1990). "Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney.". J. Biol. Chem. 265 (15): 8795–801. PMID 2111324.
• Carter ND, Fryer A, Grant AG, Hume R, Strange RG, Wistrand PJ (1990). "Membrane specific carbonic anhydrase (CAIV) expression in human tissues.". Biochim. Biophys. Acta 1026 (1): 113–6. doi:10.1016/0005-2736(90)90340-T. PMID 2116168.
• Whitney PL, Briggle TV (1982). "Membrane-associated carbonic anhydrase purified from bovine lung.". J. Biol. Chem. 257 (20): 12056–9. PMID 6811592.
• Bardien S, Ebenezer N, Greenberg J, Inglehearn CF, Bartmann L, Goliath R, Beighton P, Ramesar R, Bhattacharya SS (1995). "An eighth locus for autosomal dominant retinitis pigmentosa is linked to chromosome 17q.". Hum. Mol. Genet. 4 (8): 1459–62. doi:10.1093/hmg/4.8.1459. PMID 7581389.
• Okuyama T, Waheed A, Kusumoto W, Zhu XL, Sly WS (1995). "Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity.". Arch. Biochem. Biophys. 320 (2): 315–22. doi:10.1016/0003-9861(95)90015-2. PMID 7625839.
• Mahieu I, Benjamin A, Stephens R, Walters D, Carter N (1995). "Characterization of membrane bound carbonic anhydrase IV (CA IV) located on the external surface of lung pulmonary endothelial cells.". Biochem. Soc. Trans. 23 (2): 320S. PMID 7672351.
• Sender S, Gros G, Waheed A, Hageman GS, Sly WS (1994). "Immunohistochemical localization of carbonic anhydrase IV in capillaries of rat and human skeletal muscle.". J. Histochem. Cytochem. 42 (9): 1229–36. doi:10.1177/42.9.8064130. PMID 8064130.
• Fleming RE, Parkkila S, Parkkila AK, Rajaniemi H, Waheed A, Sly WS (1996). "Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization.". J. Clin. Invest. 96 (6): 2907–13. doi:10.1172/JCI118362. PMC 186002. PMID 8675662.
• Waheed A, Okuyama T, Heyduk T, Sly WS (1996). "Carbonic anhydrase IV: purification of a secretory form of the recombinant human enzyme and identification of the positions and importance of its disulfide bonds.". Arch. Biochem. Biophys. 333 (2): 432–8. doi:10.1006/abbi.1996.0412. PMID 8809084.
• Parkkila S, Parkkila AK, Juvonen T, Waheed A, Sly WS, Saarnio J, Kaunisto K, Kellokumpu S, Rajaniemi H (1996). "Membrane-bound carbonic anhydrase IV is expressed in the luminal plasma membrane of the human gallbladder epithelium.". Hepatology 24 (5): 1104–8. doi:10.1002/hep.510240521. PMID 8903383.
• Stams T, Nair SK, Okuyama T, Waheed A, Sly WS, Christianson DW (1997). "Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13589–94. doi:10.1073/pnas.93.24.13589. PMC 19359. PMID 8942978.
• Bardien S, Ramesar R, Bhattacharya S, Greenberg J (1997). "Retinitis pigmentosa locus on 17q (RP17): fine localization to 17q22 and exclusion of the PDEG and TIMP2 genes.". Hum. Genet. 101 (1): 13–7. doi:10.1007/s004390050577. PMID 9385361.
• Sender S, Decker B, Fenske CD, Sly WS, Carter ND, Gros G (1998). "Localization of carbonic anhydrase IV in rat and human heart muscle.". J. Histochem. Cytochem. 46 (7): 855–61. doi:10.1177/002215549804600709. PMID 9632745.
• Wistrand PJ, Carter ND, Conroy CW, Mahieu I (1999). "Carbonic anhydrase IV activity is localized on the exterior surface of human erythrocytes.". Acta Physiol. Scand. 165 (2): 211–8. doi:10.1046/j.1365-201x.1999.00478.x. PMID 10090333.
• Fujikawa-Adachi K, Nishimori I, Sakamoto S, Morita M, Onishi S, Yonezawa S, Hollingsworth MA (1999). "Identification of carbonic anhydrase IV and VI mRNA expression in human pancreas and salivary glands.". Pancreas 18 (4): 329–35. doi:10.1097/00006676-199905000-00001. PMID 10231836.
• Sterling D, Alvarez BV, Casey JR (2002). "The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV.". J. Biol. Chem. 277 (28): 25239–46. doi:10.1074/jbc.M202562200. PMID 11994299.

External links

• GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview