Carotene epsilon-monooxygenase

Carotene epsilon-monooxygenase (EC 1.14.99.45, CYP97C1, LUT1) is an enzyme with systematic name alpha-carotene:oxygen oxidoreductase (3-hydroxylating).^[1]^[2] This enzyme catalyses the following chemical reaction

alpha-carotene + O₂ + AH₂

\rightleftharpoons

alpha-cryptoxanthin + A + H₂O

Carotene epsilon-monooxygenase is a heme-thiolate protein (P450).

References

↑ Pogson, B., McDonald, K.A., Truong, M., Britton, G. and DellaPenna, D. (1996). "Arabidopsis carotenoid mutants demonstrate that lutein is not essential for photosynthesis in higher plants". Plant Cell 8 (9): 1627–1639. doi:10.1105/tpc.8.9.1627. PMC 161303. PMID 8837513.
↑ Tian, L., Musetti, V., Kim, J., Magallanes-Lundback, M. and DellaPenna, D. (2004). "The Arabidopsis LUT1 locus encodes a member of the cytochrome P₄₅₀ family that is required for carotenoid ε-ring hydroxylation activity". Proc. Natl. Acad. Sci. USA 101 (1): 402–407. doi:10.1073/pnas.2237237100. PMC 314197. PMID 14709673.

External links

Carotene epsilon-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)

1.14.11: 2-oxoglutarate	Prolyl hydroxylase Lysyl hydroxylase

1.14.13: NADH or NADPH	Flavin-containing monooxygenase FMO1 FMO2 FMO3 FMO4 FMO5 Nitric oxide synthase NOS1 NOS2 NOS3 Cholesterol 7 alpha-hydroxylase Methane monooxygenase 3A4 Lanosterol 14 alpha-demethylase 24-hydroxycholesterol 7α-hydroxylase

1.14.14: reduced flavin or flavoprotein	19A1 2D6 2E1

1.14.15: reduced iron-sulfur protein	11B1 11B2 11A1

1.14.16: reduced pteridine (BH4 dependent)	Phenylalanine hydroxylase Tyrosine hydroxylase Tryptophan hydroxylase

1.14.17: reduced ascorbate	Dopamine beta-hydroxylase

1.14.18-19: other	Tyrosinase Stearoyl-CoA desaturase-1

1.14.99 - miscellaneous	Cyclooxygenase Heme oxygenase (HMOX1) Squalene monooxygenase 17A1 21A2

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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