Recaldent

Recaldent, with the technical name casein phosphopeptide – amorphous calcium phosphate, or CPP-ACP, is a milk-derived product that is claimed to remineralize teeth and help prevent dental caries, also known as tooth decay.

The scientific research which led to the development of Recaldent™ began in the 1980s. Over 20 years, researchers at the Melbourne Dental School (University of Melbourne), led by Professor Eric Reynolds, investigated the casein protein in milk until they were able to identify and isolate the CPP-ACP complex.

Properties

Casein phosphopeptides (CPP) from the major protein of milk have the ability to stabilize calcium, phosphate and fluoride ions as water-soluble amorphous complexes that provide bioavailable calcium, phosphate and fluoride ions to the tooth.[1][2][3] These complexes of amorphous calcium phosphate and amorphous calcium fluoride phosphate stabilized by the CPP have been demonstrated in a range of laboratory, animal and short-term human clinical trials to repair (remineralise) early stages of tooth decay by replacing the calcium and phosphate ions lost due to decay.[4][5] Three longer-term, randomized, controlled clinical trials have demonstrated the efficacy of CPP-ACP in slowing the progression of dental caries and in regressing (repairing) early stages of tooth decay.[6][7][8] Another randomly controlled trial showed that CPP and calcium carbonate in a toothpaste formulation, which would spontaneously form CPP-ACP in saliva, significantly reduced caries experience in children compared with a control toothpaste.[9] A systematic review with meta-analysis by Yengopal and Mickenautsch[10] concluded that “the results of the clinical in situ trials indicate a short-term remineralization effect of CPP-ACP. Additionally, the promising in vivo RCT results suggest a caries-preventing effect for long-term clinical CPP-ACP use”. Recaldent (CPP-ACP) can be applied to the teeth via sugar-free gum, medicated tooth crème and fortified dairy milk.

See also

References

  1. ↑ Cross KJ, Huq NL, Palamara JE, Perich JW, Reynolds EC (2005). “Physicochemical characterization of casein phosphopeptide-amorphous calcium phosphate nanocomplexes.” Journal of Biological Chemistry 280:15362-15369. PMID 19704195. DOI 10.1074/jbc.M413504200.
  2. ↑ Cross KJ, Huq NL, Stanton D, Sum M, Reynolds EC (2004). “NMR studies of a novel calcium, phosphate and fluoride delivery vehicle aS1-casein(59-79) by stabilized amorphous calcium fluoride phosphate nanocomplexes.” Biomaterials 25: 5061-5069. PMID 15109869.DOI 10.1016/j.biomaterials.2004.01.045.
  3. ↑ Cochrane NJ, Cai F, Huq NL, Burrow MF, Reynolds EC (2010)."New Approaches to Enhanced Remineralization of Tooth Enamel." Journal of Dental Research DOI 10.1177/0022034510376046.
  4. ↑ Reynolds EC (2009). “Casein phosphopeptide-amorphous calcium phosphate: the scientific evidence.” Advances in Dental Research 21: 25-29. PMID 19717407. DOI 10.1177/0895937409335619.
  5. ↑ Llena C, Forner L, Baca P (2009). “Anticariogenicity of casein phosphopeptide-amorphous calcium phosphate: A review of the literature.” Journal of Contemporary Dental Practice 10:1-9. PMID 19430620.
  6. ↑ Andersson A, Sköld-Larsson K, Hallgren A, Petersson LG, Twetman S (2007). “Effect of a dental cream containing amorphous calcium phosphate complexes on white spot lesion regression assessed by laser fluorescence.” Oral Health & Preventive Dentistry 5:229-233. PMID 17977295.
  7. ↑ Morgan MV, Adams GG, Bailey DL, Tsao CE, Fischman SL, Reynolds EC (2008). “The anticariogenic effect of sugar-free gum containing CPP-ACP nanocomplexes on approximal caries determined using digital bitewing radiography.” Caries Research 42:171-184. PMID 18446025. DOI 10.1159/000128561.
  8. ↑ Bailey DL, Adams GG, Tsao CE, Hyslop A, Escobar K, Manton DJ, Reynolds EC, Morgan MV (2009). “Regression of post-orthodontic lesions by a remineralizing cream.” Journal of Dental Research 88:1148–1153. PMID 19887683. DOI 10.1177/0022034509347168.
  9. ↑ Rao SK, Bhat GS, Aradhya S, Devi A, Bhat M (2009). “Study of the efficacy of toothpaste containing casein phosphopeptide in the prevention of dental caries: a randomized controlled trial in 12- to 15-year-old high caries risk children in Bangalore, India.” Caries Research 43:430-435. PMID 19864905. DOI 10.1159/000252976.
  10. ↑ Yengopal V, Mickenautsch S (2009). “Caries preventive effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP): a meta-analysis.” Acta Odontologica Scandinavica 21:321-332. PMID 19701818. DOI 10.1080/00016350903160563.

External links

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