Cerium(III) chloride

Cerium(III) chloride
Names
IUPAC names
Cerium(III) chloride
Cerium trichloride
Other names
Cerous chloride
Identifiers
7790-86-5 YesY
18618-55-8 (heptahydrate) N
ChEBI CHEBI:35458 YesY
ChemSpider 23038 YesY
Jmol interactive 3D Image
PubChem 24636
UNII TH8E3IE00V N
Properties
CeCl3
Molar mass 246.48 g/mol (anhydrous)
372.58 g/mol (heptahydrate)
Appearance fine white powder
Density 3.97 g/cm3
Melting point 817 °C (1,503 °F; 1,090 K) (anhydrous)
90 °C (heptahydrate, decomposes)
Boiling point 1,727 °C (3,141 °F; 2,000 K)
100 g/100 ml
Solubility soluble in alcohol
Structure
hexagonal (UCl3 type), hP8
P63/m, No. 176
Tricapped trigonal prismatic
(nine-coordinate)
Hazards
Not listed
Flash point Non-flammable
Related compounds
Other anions
 Cerium(III) oxide
Cerium(III) fluoride
Cerium(III) bromide
Cerium(III) iodide
Other cations
 Lanthanum(III) chloride
Praseodymium(III) chloride
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Cerium(III) chloride (CeCl3), also known as cerous chloride or cerium trichloride, is a compound of cerium and chlorine. It is a white hygroscopic solid; it rapidly absorbs water on exposure to moist air to form a hydrate, which appears to be of variable composition,[1] though the heptahydrate CeCl3·7 H2O is known. It is highly soluble in water, and (when anhydrous) it is soluble in ethanol and acetone.[2]

Preparation of anhydrous CeCl3

Simple rapid heating of the hydrate alone may cause small amounts of hydrolysis.[3] A useful form of anhydrous CeCl3 can be prepared if care is taken to heat the heptahydrate gradually to 140 °C (284 °F) over many hours under vacuum.[2][4][5] This may or may not contain a little CeOCl from hydrolysis), but it is suitable for use with organolithium and Grignard reagents. Pure anhydrous CeCl3 can be made by dehydration of the hydrate either by slowly heating to 400 °C (752 °F) with 4–6 equivalents of ammonium chloride under high vacuum,[3][6][7][8] or by heating with an excess of thionyl chloride for three hours.[3][9] The anhydrous halide may alternatively be prepared from cerium metal and hydrogen chloride.[10][11] It is usually purified by high temperature sublimation under high vacuum.

Uses

Cerium(III) chloride can be used as a starting point for the preparation of other cerium salts, such as the Lewis acid, cerium(III) trifluoromethanesulfonate, used for Friedel-Crafts acylations. It is also used itself as a Lewis acid, for example as a catalyst in Friedel-Crafts alkylation reactions.[12]

Luche reduction[13] of alpha, beta-unsaturated carbonyl compounds has become a popular method in organic synthesis, where CeCl3·7H2O is used in conjunction with sodium borohydride. For example carvone gives only the allylic alcohol 1 and none of the saturated alcohol 2. Without CeCl3, a mixture of 1 and 2 is formed.

Another important use in organic synthesis is for alkylation of ketones, which would otherwise form enolates if simple organolithium reagents were to be used. For example, compound 3 would be expected to simply form an enolate without CeCl3 being present, but in the presence of CeCl3 smooth alkylation occurs:[4]

It is reported that organolithiums work more effectively in this reaction than do Grignard reagents.[4]

References

  1. ↑ Several major manufacturers such as Alfa and Strem list their products simply as a "hydrate" with "xH2O" in the formula, but Aldrich sells a heptahydrate.
  2. 1 2 Paquette, L. A. (1999). Coates, R. M.; Denmark, S. E. (eds.), ed. Handbook of Reagents for Organic Synthesis: Reagents, Auxiliaries and Catalysts for C-C Bond Formation. New York: Wiley. ISBN 0-471-97924-4.
  3. 1 2 3 Edelmann, F. T.; Poremba, P. (1997). Herrmann, W. A. (ed.), ed. Synthetic Methods of Organometallic and Inorganic Chemistry VI. Stuttgart: Georg Thieme Verlag. ISBN 3-13-103021-6.
  4. 1 2 3 Johnson, C. R.; Tait, B. D. (1987). "A cerium(III) modification of the Peterson reaction: methylenation of readily enolizable carbonyl compounds". Journal of Organic Chemistry 52 (2): 281–283. doi:10.1021/jo00378a024. ISSN 0022-3263.
  5. ↑ Dimitrov, Vladimir; Kostova, Kalina; Genov, Miroslav (1996). "Anhydrous cerium(III) chloride — Effect of the drying process on activity and efficiency". Tetrahedron Letters 37 (37): 6787–6790. doi:10.1016/S0040-4039(96)01479-7.
  6. ↑ Taylor, M. D.; Carter, P. C. (1962). "Preparation of anhydrous lanthanide halides, especially iodides". Journal of Inorganic and Nuclear Chemistry 24 (4): 387–391. doi:10.1016/0022-1902(62)80034-7.
  7. ↑ Kutscher, J.; Schneider, A. (1971). "Notiz zur Präparation von wasserfreien Lanthaniden-Haloge-niden, Insbesondere von Jodiden". Inorg. Nucl. Chem. Lett. 7 (9): 815. doi:10.1016/0020-1650(71)80253-2.
  8. ↑ Greenwood, N. N.; Earnshaw, A. (1984). Chemistry of the Elements. New York: Pergamon Press. ISBN 0-08-022056-8.
  9. ↑ Freeman, J. H.; Smith, M. L. (1958). "The preparation of anhydrous inorganic chlorides by dehydration with thionyl chloride". Journal of Inorganic and Nuclear Chemistry 7 (3): 224–227. doi:10.1016/0022-1902(58)80073-1.
  10. ↑ Druding, L. F.; Corbett, J. D. (1961). "Lower Oxidation States of the Lanthanides. Neodymium(II) Chloride and Iodide". Journal of the American Chemical Society 83 (11): 2462–2467. doi:10.1021/ja01472a010. ISSN 0002-7863.
  11. ↑ Corbett, J. D. (1973). Rev. Chim. Minerale 10: 239. Missing or empty |title= (help)
  12. ↑ Mine, Norioki; Fujiwara, Yuzo; Taniguchi, Hiroshi (1986). "Trichlorolanthanoid (LnCl3)-catalyzed Friedel-Crafts alkylation reactions". Chemistry Letters 15 (3): 357–360. doi:10.1246/cl.1986.357.
  13. ↑ Luche, Jean-Louis; Rodriguez-Hahn, Lydia; Crabbé, Pierre (1978). "Reduction of natural enones in the presence of cerium trichloride". Journal of the Chemical Society, Chemical Communications (14): 601–602. doi:10.1039/C39780000601.

Further reading

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