Chidamide
 | |
| Systematic (IUPAC) name | |
|---|---|
|
N-(2-Amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide | |
| Clinical data | |
| Trade names | Epidaza |
| Identifiers | |
| CAS Number | 743420-02-2 |
| UNII |
87CIC980Y0  |
| Chemical data | |
| Formula | C22H19FN4O2 |
| Molar mass | 390.4 g/mol |
| |
Chidamide (Epidaza) is an HDAC inhibitor (HDI) developed wholly in China.[1] Originally known as HBI-8000.[2]
It is a benzamide HDI) and inhibits Class I HDAC1, HDAC2, HDAC3, as well as Class IIb HDAC10 [3]
It is approved by the Chinese FDA for relapsed or refractory peripheral T-cell lymphoma (PTCL), and having Orphan drug status in Japan.[2]
As of April 2015 it is only approved in China.[1]
It shows potential in treating pancreatic cancer.[4][5][6]
Is NOT approved for the treatment of pancreatic cancer.
References
- 1 2 "China's First Homegrown Pharma.". April 2015.
- 1 2
- ↑ HUYA Bioscience International Grants An Exclusive License For HBI-8000 In Japan And Other Asian Countries To Eisai. Feb 2016
- ↑ Qiao, Z (2013-04-26). "Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells.". Biochem Biophys Res Commun. 434 (1): 95–101. doi:10.1016/j.bbrc.2013.03.059. PMID 23541946.
- ↑ Guha, Malini (2015-04-01). "HDAC inhibitors still need a home run, despite recent approval". Nature Reviews Drug Discovery 14: 225–226. doi:10.1038/nrd4583.
- ↑ Wang, Shirley S. (2015-04-02). "A New Cancer Drug, Made in China". The Wall Street Journal. Retrieved 13 April 2015.
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