Benzamide
Names | |
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IUPAC name
Benzamide | |
Other names
Benzoic acid amide, Phenyl carboxamide, Benzoylamide | |
Identifiers | |
55-21-0 | |
ChEBI | CHEBI:28179 |
ChEMBL | ChEMBL267373 |
ChemSpider | 2241 |
EC Number | 200-227-7 |
Jmol interactive 3D | Image Image |
KEGG | C09815 |
PubChem | 2331 |
RTECS number | CU8700000 |
UNII | 6X80438640 |
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Properties | |
C7H7NO | |
Molar mass | 121.14 g·mol−1 |
Appearance | Off-white solid |
Density | 1.341 g/cm3 |
Melting point | 127 to 130 °C (261 to 266 °F; 400 to 403 K) |
Boiling point | 288 °C (550 °F; 561 K) |
13 g/l | |
Acidity (pKa) | 23.35 (in DMSO) |
Pharmacology | |
ATC code | N05 |
Hazards | |
EU classification (DSD) |
Harmful (Xn) |
R-phrases | R22 R40 |
S-phrases | S36/37/39 |
NFPA 704 | |
Flash point | 180 °C (356 °F; 453 K) |
> 500 °C (932 °F; 773 K) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
Benzamide is an off-white solid with the chemical formula of C6H5CONH2. It is a derivative of benzoic acid. It is slightly soluble in water, and soluble in many organic solvents.
Chemical derivatives
A number of substituted benzamides exist, including:
- Analgesics
- Antiemetics/Prokinetics
- Alizapride
- Batanopride
- Bromopride
- Cinitapride
- Cisapride
- Clebopride
- Dazopride
- Domperidone
- Itopride
- Metoclopramide
- Mosapride
- Prucalopride
- Renzapride
- Trimethobenzamide
- Zacopride
- Antipsychotics
- Others
- Entinostat
- Eticlopride
- Mocetinostat
- Raclopride
- Procarbazine
- Pyramide (pyridinyl ethylbenzimide)[1]
The sedatives trimetozine, and tricetamide, the CNS stimulants ethamivan, and nikethamide, the anthelmintic agents niclosamide, clioxanide and bromoxanide, the coccidiostat aklomide, and the antiarrhythmic agent capobenic acid are all made from the corresponding benzoic acids in obvious ways.
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Bromoxanide (SKF 61636)
See also
References
- ↑ Singh, K. N. and Merchant, Kavita (2012). "The Agrochemical Industry, Annex 17.1". In Kent, James A. Handbook of Industrial Chemistry and Biotechnology. New York: Springer Verlag. pp. 643–698 page 693. doi:10.1007/978-1-4614-4259-2_17.
External links
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