Aceperone

Aceperone
Systematic (IUPAC) name

N-({1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-phenyl-4-piperidinyl}methyl)acetamide
Identifiers
CAS Number	807-31-8
ATC code	none
PubChem	CID 13122
ChemSpider	12570
UNII	S69KXZ59AB
ChEMBL	CHEMBL136298
Synonyms	Acetabuton; R 3248
Chemical data
Formula	C₂₄H₂₉FN₂O₂
Molar mass	396.498 g/mol
SMILES Fc1ccc(cc1)C(=O)CCCN3CCC(c2ccccc2)(CC3)CNC(=O)C
InChI InChI=1S/C24H29FN2O2/c1-19(28)26-18-24(21-6-3-2-4-7-21)13-16-27(17-14-24)15-5-8-23(29)20-9-11-22(25)12-10-20/h2-4,6-7,9-12H,5,8,13-18H2,1H3,(H,26,28) Key:VDGZERMDPAAZEJ-UHFFFAOYSA-N
Physical data
Melting point	97 to 100 °C (207 to 212 °F) ^[1]

Aceperone is a neuroleptic drug of the butyrophenone class. It is an α-noradrenergic blocking drug developed by Janssen Pharmaceutica in the 1960s.^[1]

Because of its learning impairment effects in animals, aceperone has been used as a tool in the study of the biochemical basis of learning.^[2]^[3]^[4]

References

1 2 Alkoxylamino and alkoxycarbonylamino derivatives of 1(aroylalkyl)-4-arylpiperidines. Janssen, Paul A. J. (1961) BE 606849
↑ Ridley, R. M.; Haystead, T. A. J.; Baker, H. F.; Crow, T. J. (1981). "A new approach to the role of noradrenaline in learning: problem-solving in the marmoset after α-noradrenergic receptor blockade". Pharmacology, Biochemistry and Behavior 14 (6): 849–855. doi:10.1016/0091-3057(81)90373-7.
↑ Baker, H.F.; Ridley, R.M.; Haystead, T.A.J.; Crow, T.J. (1983). "Further consideration of the learning impairment after aceperone in the marmoset: Effects of the drug on shape and colour discrimination and on an alternation task". Pharmacology Biochemistry and Behavior 18 (5): 701. doi:10.1016/0091-3057(83)90009-6.
↑ Scraggs, P. R.; Ridley, R. M. (1979). "The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset". Psychopharmacology 62 (1): 41–5. doi:10.1007/BF00426033. PMID 155838.

Antipsychotics (neuroleptics) (N05A)

Typical	Benzamides Levosulpiride Sulpiride Veralipride^‡ Butyrophenones Aceperone Azaperone Benperidol Bromperidol Droperidol Fluanisone Haloperidol^# Lenperone Moperone Pipamperone Spiperone Timiperone Trifluperidol Diphenylbutylpiperidines Clopimozide Fluspirilene Penfluridol Pimozide Phenothiazines Acepromazine Acetophenazine Butaperazine Carphenazine Chloracizine Chlorproethazine Chlorpromazine Cyamemazine Dixyrazine Fluacizine Fluphenazine Levomepromazine/Methotrimeprazine Mesoridazine Perazine Periciazine Perphenazine Perphenazine 4-aminobutyrate Piperacetazine Pipotiazine Prochlorperazine Promazine Promethazine Propiomazine Sulforidazine Thiethylperazine Thiopropazate Thioproperazine Thioridazine Trifluoperazine Triflupromazine Thioxanthenes Chlorprothixene Clopenthixol Clothixamide Flupentixol Fluprothixene Piflutixol Teflutixol Thiothixene Zuclopenthixol Tricyclics Fluotracen Loxapine Trimipramine Others Butaclamol Prothipendyl

Atypical	Benzamides Amisulpride Nemonapride Remoxipride^‡ Sultopride Tiapride Butyrophenones Cinuperone Melperone Setoperone Benzo(iso)oxazole piperidines Iloperidone Ocaperidone^§ Paliperidone Risperidone^# Benzo(iso)thiazole piperazines Lurasidone Perospirone Revospirone^§ Tiospirone^§ Ziprasidone Diphenylbutylpiperazines Amperozide Phenylpiperazines Aripiprazole Aripiprazole lauroxil Bifeprunox^§ Brexpiprazole Cariprazine Tricyclics Amoxapine Asenapine Carpipramine Clocapramine Clorotepine Clotiapine Clozapine^# Fluperlapine Gevotroline Metitepine Mosapramine Olanzapine Quetiapine Tenilapine Zotepine Others Blonanserin ITI-007^† Molindone Pimavanserin RP5063^† Sertindole Zicronapine^§

Others	Azacyclonol Cannabidiol Oxypertine Reserpine Tetrabenazine

^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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