Oxypertine

Oxypertine

Systematic (IUPAC) name
5,6-dimethoxy-2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
Legal status	℞ (Prescription only)
Identifiers
CAS Number	153-87-7
ATC code	N05AE01 (WHO)
PubChem	CID 4640
ChemSpider	4479
UNII	5JGL4G25R7
KEGG	D01219
Chemical data
Formula	C23H29N3O2
Molar mass	379.49 g/mol
SMILES CC1=C(C2=CC(=C(C=C2N1)OC)OC)CCN3CCN(CC3)C4=CC=CC=C4
InChI InChI=1S/C23H29N3O2/c1-17-19(20-15-22(27-2)23(28-3)16-21(20)24-17)9-10-25-11-13-26(14-12-25)18-7-5-4-6-8-18/h4-8,15-16,24H,9-14H2,1-3H3 Key:XCWPUUGSGHNIDZ-UHFFFAOYSA-N
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Oxypertine (Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil) is an antipsychotic used in the treatment of schizophrenia.^[1] It was also evaluated for the treatment of anxiety at a dosage of 20mg/d.^[2] Chemically, it is an indole derivative similarly to molindone and a member of the phenylpiperazine class.^[3] Like reserpine and tetrabenazine, oxypertine depletes catecholamines, though not serotonin, possibly underlying its neuroleptic efficacy.^[4] The molecular structure is strongly similar to solypertine and milipertine.

References

1. Hall, Chapman and; Rhodes, P. H (1996). Dictionary of organic compounds. London: Chapman & Hall. ISBN 0-412-54090-8.
2. Somohano MD, Broissin MC, Sobrino z A. [Clinical evaluation of oxypertine in anxiety conditions]. Neurol Neurocir Psiquiatr. 1976;17(3):171-80.
3. Breulet M, Labar P, Delree C, Collard J, Bobon J (February 1968). "[Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties]". Acta Neurol Psychiatr Belg (in French) 68 (2): 116–27. PMID 4972600.
4. Bak IJ, Hassler R, Kim JS (1969). "Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin". Zeitschrift für Zellforschung und Mikroskopische Anatomie (Vienna, Austria : 1948) 101 (3): 448–62. PMID 5362847.